My NCBISign In

Display Settings:

Format

Send to:

Choose Destination
    J Biol. 2009;8(3):30. Epub 2009 Apr 15.

    Exploiting the promiscuity of imatinib.

    Lee SJ, Wang JY.

    Source

    Department of Medicine and Division of Hematology-Oncology, 3855 Health Sciences Drive, University of California-San Diego, La Jolla, CA 92093, USA.

    Erratum in

    • J Biol. 2010;8:82.

    Abstract

    The protein kinase inhibitor imatinib, also known as Gleevec, has been a notable success in treating chronic myelogenous leukemia. A recent paper in BMC Structural Biology reports a 1.75 A crystal structure of imatinib bound to the oxidoreductase NQO2 and reveals insights into the binding specificity and the off-target effects of the inhibitor.

    PMID:
    19435483
    [PubMed - indexed for MEDLINE]
    PMCID: PMC2689438
    Free PMC Article

    Images from this publication.See all images (2) Free text

    Figure 2
    Figure 1

    Publication Types, MeSH Terms, Substances, Grant Support

    Publication Types

    MeSH Terms

    Substances

    Grant Support

    LinkOut - more resources

    Full Text Sources

    Molecular Biology Databases

    Libraries

      Supplemental Content

      Click here to read Click here to read

      Related citations

      See reviews... See all...

      Chemical compound information

      See 7 citations for this compound....

      Related information

      • Related Citations
        Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
      • Compound (MeSH Keyword)
        PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
      • References for this PMC Article
        Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
      • Substance (MeSH Keyword)
        PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
      • Free in PMC
        Free full text articles in PMC

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...
      You are here: NCBI > Literature > PubMed
      Write to the Help Desk