Immunogenetics. 2009 Jun;61(6):463-81. Epub 2009 Apr 30.

Origin and evolution of the vertebrate leukocyte receptors: the lesson from tunicates.

Zucchetti I, De Santis R, Grusea S, Pontarotti P, Du Pasquier L.

Source

Laboratory of Animal Physiology and Evolution, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy. ivana.zucchetti@szn.it

Abstract

Two selected receptor genes of the immunoglobulin superfamily (IgSF), one CTX/JAM family member, and one poliovirus receptor-like nectin that have features of adhesion molecules can be expressed by Ciona hemocytes, the effectors of immunity. They can also be expressed in the nervous system (CTX/JAM) and in the ovary (nectin). The genes encoding these receptors are located among one set of genes, spread over Ciona chromosomes 4 and 10, and containing other IgSF members homologous to those encoded by genes present in a tetrad of human (1, 3 + X, 11, 21 + 19q) or bird chromosomes (1, 4, 24, 31) that include the leukocyte receptor complex. It is proposed that this tetrad is due to the two rounds of duplication that affected a single prevertebrate ancestral region containing a primordial leukocyte receptor complex involved in immunity and other developmental regulatory functions.

PMID:: 19404636; [PubMed - indexed for MEDLINE]

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