Warning: The NCBI web site requires JavaScript to function. more...

My NCBI Sign In

Cardiovasc Diabetol. 2009 Apr 29;8:23.

Postprandial hyperglycemia as an etiological factor in vascular failure.

Node K, Inoue T.

Source

Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, Saga, Japan. inouete@med.saga-u.ac.jp

Abstract

Postprandial hyperglycemia is characterized by hyperglycemic spikes that induce endothelial dysfunction, inflammatory reactions and oxidative stress, which may lead to progression of atherosclerosis and occurrence of cardiovascular events. Emerging data indicate that postprandial hyperglycemia or even impaired glucose tolerance may predispose to progression of atherosclerosis and cardiovascular events. There is evidence that postprandial hyperglycemia, but not fasting hyperglycemia, independently predicts the occurrence of cardiovascular events. We proposed a concept of 'vascular failure' as a comprehensive syndrome of vascular dysfunction extending from risk factors to advanced atherosclerotic disease. Postprandial hyperglycemia is therefore one of the very important pathophysiological states contributing to vascular failure. Accordingly, controlling postprandial hyperglycemia should be the focus of future clinical investigation as a potential target for preventing vascular failure.

PMID:: 19402896; [PubMed - indexed for MEDLINE]
PMCID: PMC2688503

Free PMC Article

Images from this publication.See all images (6) Free text

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Vascular Diseases - MedlinePlus Health Information

Libraries

LinkOut Holdings

Supplemental Content

Click here to read

Click here to read

Related citations

Review The post-prandial state and macrovascular disease: relevance to diabetes mellitus. [J Assoc Physicians India. 2001]
Review The post-prandial state and macrovascular disease: relevance to diabetes mellitus.
Shah SN, Joshi SR. J Assoc Physicians India. 2001 Jan 25; 49 Spec No:32, 37-41.
Review Should postprandial hyperglycaemia in prediabetic and type 2 diabetic patients be treated? [Drugs. 2006]
Review Should postprandial hyperglycaemia in prediabetic and type 2 diabetic patients be treated?
Charpentier G, Riveline JP, Dardari D, Varroud-Vial M. Drugs. 2006; 66(3):273-86.
Review Postprandial hyperglycaemia and vascular damage--the benefits of acarbose. [Diab Vasc Dis Res. 2006]
Review Postprandial hyperglycaemia and vascular damage--the benefits of acarbose.
Båvenholm PN, Efendic S. Diab Vasc Dis Res. 2006 Sep; 3(2):72-9.
Review [Postprandial hyperglycemia. Cardiovascular risks and new therapeutic strategies]. [Lakartidningen. 2001]
Review [Postprandial hyperglycemia. Cardiovascular risks and new therapeutic strategies].
Sjöholm A. Lakartidningen. 2001 Feb 28; 98(9):937-40.
Review Vascular endothelium as a target of beraprost sodium and fenofibrate for antiatherosclerotic therapy in type 2 diabetes mellitus. [Vasc Health Risk Manag. 2005]
Review Vascular endothelium as a target of beraprost sodium and fenofibrate for antiatherosclerotic therapy in type 2 diabetes mellitus.
Otsuki M, Goya K, Kasayama S. Vasc Health Risk Manag. 2005; 1(3):209-15.

See reviews... See all...

Cited by 6 PubMed Central articles

Effects of calcium channel blockers on glucose tolerance, inflammatory state, and circulating progenitor cells in non-diabetic patients with essential hypertension: a comparative study between Azelnidipine and amlodipine on glucose tolerance and endothelial function - a crossover trial (AGENT). [Cardiovasc Diabetol. 2011]
Effects of calcium channel blockers on glucose tolerance, inflammatory state, and circulating progenitor cells in non-diabetic patients with essential hypertension: a comparative study between Azelnidipine and amlodipine on glucose tolerance and endothelial function - a crossover trial (AGENT).
Fukao K, Shimada K, Hiki M, Kiyanagi T, Hirose K, Kume A, Ohsaka H, Matsumori R, Kurata T, Miyazaki T, et al. Cardiovasc Diabetol. 2011 Sep 10; 10:79. Epub 2011 Sep 10.
Impaired fasting glucose is associated with increased perioperative cardiovascular event rates in patients undergoing major non-cardiothoracic surgery. [Cardiovasc Diabetol. 2011]
Impaired fasting glucose is associated with increased perioperative cardiovascular event rates in patients undergoing major non-cardiothoracic surgery.
Biteker M, Dayan A, Can MM, İlhan E, Biteker FS, Tekkeşin A, Duman D. Cardiovasc Diabetol. 2011 Jul 14; 10:63. Epub 2011 Jul 14.
The association of brachial-ankle pulse wave velocity with 30-minute post-challenge plasma glucose levels in korean adults with no history of type 2 diabetes. [Korean Diabetes J. 2010]
The association of brachial-ankle pulse wave velocity with 30-minute post-challenge plasma glucose levels in korean adults with no history of type 2 diabetes.
Choi ES, Rhee EJ, Choi JH, Bae JC, Yoo SH, Kim WJ, Park SE, Park CY, Lee WY, Cho YK, et al. Korean Diabetes J. 2010 Oct; 34(5):287-93. Epub 2010 Oct 31.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Postprandial hyperglycemia as an etiological factor in vascular failure.
Postprandial hyperglycemia as an etiological factor in vascular failure.
Cardiovasc Diabetol. 2009 Apr 29 ;8:23.

PubMed
Imaging of gout: findings and utility.
Imaging of gout: findings and utility.
Arthritis Res Ther. 2009 ;11(3):232. Epub 2009 Jun 17 .

PubMed
Reproductive tract infections in women seeking abortion in Vietnam.
Reproductive tract infections in women seeking abortion in Vietnam.
BMC Womens Health. 2009 Jan 29 ;9:1.

PubMed
Prolonged treatment of genetically obese mice with conjugated linoleic acid impr...
Prolonged treatment of genetically obese mice with conjugated linoleic acid improves glucose tolerance and lowers plasma insulin concentration: possible involvement of PPAR activation.
Lipids Health Dis. 2005 Jan 10 ;4:3.

PubMed
A prospective study of androgen levels, hormone-related genes and risk of rheuma...
A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis.
Arthritis Res Ther. 2009 ;11(3):R97. Epub 2009 Jun 25 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...

You are here: NCBI > Literature > PubMed

Write to the Help Desk