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    J Cell Physiol. 2009 Aug;220(2):485-91.

    Mechanism of growth inhibition by MicroRNA 145: the role of the IGF-I receptor signaling pathway.

    La Rocca G, Badin M, Shi B, Xu SQ, Deangelis T, Sepp-Lorenzinoi L, Baserga R.

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    Department of Cancer Biology at Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA 19107, USA.

    Abstract

    MicroRNA 145 (miR145) has been proposed as a tumor suppressor. It was previously shown that miR145 targets the 3' UTR of the insulin receptor substrate-1 (IRS-1) and dramatically inhibits the growth of colon cancer cells. miR145 also targets the type 1 insulin-like growth factor receptor (IGF-IR). We show here that an IRS-1 lacking its 3' UTR is no longer down-regulated by miR145 and rescues colon cancer cells from miR145-induced inhibition of growth. An IGF-IR resistant to miR145 (again by elimination of its 3' UTR) is not down-regulated by miR145 but fails to rescue colon cancer cells from growth inhibition. These and other results, taken together, indicate that down-regulation of IRS-1 plays a significant role in the tumor suppressor activity of miR145.

    PMID:
    19391107
    [PubMed - indexed for MEDLINE]

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