Warning: The NCBI web site requires JavaScript to function. more...

My NCBI Sign In

J Virol. 2009 Jul;83(13):6941-6. Epub 2009 Apr 22.

Effective downregulation of HLA-A2 and HLA-B57 by primary human immunodeficiency virus type 1 isolates cultured from elite suppressors.

Nou E, Zhou Y, Nou DD, Blankson JN.

Source

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Abstract

Elite controllers or suppressors (ES) are human immunodeficiency virus type 1 (HIV-1)-infected patients who control viral replication to <50 copies/ml without antiretroviral therapy. Downregulation of HLA class I molecules is an important mechanism used by HIV-1 to evade the immune system. In this study, we showed that primary isolates from ES are as effective as isolates obtained from patients with progressive HIV-1 disease at downregulating HLA-A*2 and HLA-B*57 molecules on primary CD4(+) T cells. Thus, a diminished ability of viral isolates from ES to evade HIV-specific immune responses probably does not contribute to the control of viral replication in these patients.

PMID:: 19386719; [PubMed - indexed for MEDLINE]
PMCID: PMC2698562

Free PMC Article

Images from this publication.See all images (4) Free text

FIG. 3.

FIG. 4.

FIG. 1.

FIG. 2.

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Research Support, N.I.H., Extramural

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Medical

Libraries

LinkOut Holdings

Supplemental Content

Click here to read

Click here to read

Related citations

Evidence of CD8+ T-cell-mediated selective pressure on human immunodeficiency virus type 1 nef in HLA-B*57+ elite suppressors. [J Virol. 2009]
Evidence of CD8+ T-cell-mediated selective pressure on human immunodeficiency virus type 1 nef in HLA-B*57+ elite suppressors.
Bailey JR, Brennan TP, O'Connell KA, Siliciano RF, Blankson JN. J Virol. 2009 Jan; 83(1):88-97. Epub 2008 Oct 22.
Infrequent recovery of HIV from but robust exogenous infection of activated CD4(+) T cells in HIV elite controllers. [Clin Infect Dis. 2010]
Infrequent recovery of HIV from but robust exogenous infection of activated CD4(+) T cells in HIV elite controllers.
Julg B, Pereyra F, Buzón MJ, Piechocka-Trocha A, Clark MJ, Baker BM, Lian J, Miura T, Martinez-Picado J, Addo MM, et al. Clin Infect Dis. 2010 Jul 15; 51(2):233-8.
Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutations. [J Exp Med. 2006]
Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutations.
Bailey JR, Williams TM, Siliciano RF, Blankson JN. J Exp Med. 2006 May 15; 203(5):1357-69. Epub 2006 May 8.
Review HIV-1 replicative fitness in elite controllers. [Curr Opin HIV AIDS. 2011]
Review HIV-1 replicative fitness in elite controllers.
Lobritz MA, Lassen KG, Arts EJ. Curr Opin HIV AIDS. 2011 May; 6(3):214-20.
Review HIV-1 proteins in infected cells determine the presentation of viral peptides by HLA class I and class II molecules and the nature of the cellular and humoral antiviral immune responses--a review. [Virus Genes. 1994]
Review HIV-1 proteins in infected cells determine the presentation of viral peptides by HLA class I and class II molecules and the nature of the cellular and humoral antiviral immune responses--a review.
Becker Y. Virus Genes. 1994 Jul; 8(3):249-70.

See reviews... See all...

Cited by 2 PubMed Central articles

HIV type 1-mediated downregulation of HLA-B*57/B*5801 proteins on elite suppressor CD4+ T cells. [AIDS Res Hum Retroviruses. 2011]
HIV type 1-mediated downregulation of HLA-B*57/B*5801 proteins on elite suppressor CD4+ T cells.
Sampah ME, Ceccato CM, Blankson JN. AIDS Res Hum Retroviruses. 2011 Feb; 27(2):183-6. Epub 2010 Oct 4.
Review Effector mechanisms in HIV-1 infected elite controllers: highly active immune responses? [Antiviral Res. 2010]
Review Effector mechanisms in HIV-1 infected elite controllers: highly active immune responses?
Blankson JN. Antiviral Res. 2010 Jan; 85(1):295-302. Epub 2009 Sep 4.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Effective downregulation of HLA-A*2 and HLA-B*57 by primary human immunodeficien...
Effective downregulation of HLA-A*2 and HLA-B*57 by primary human immunodeficiency virus type 1 isolates cultured from elite suppressors.
J Virol. 2009 Jul ;83(13):6941-6. Epub 2009 Apr 22 .

PubMed
PRESTA: associating promoter sequences with information on gene expression.
PRESTA: associating promoter sequences with information on gene expression.
Genome Biol. 2002 Aug 21 ;3(9):research0050. Epub 2002 Aug 21 .

PubMed
CCL8 is a potential molecular candidate for the diagnosis of graft-versus-host d...
CCL8 is a potential molecular candidate for the diagnosis of graft-versus-host disease.
Blood. 2008 Apr 15 ;111(8):4403-12. Epub 2008 Feb 6 .

PubMed
PARP inhibitors and the treatment of breast cancer: beyond BRCA1/2?
PARP inhibitors and the treatment of breast cancer: beyond BRCA1/2?
Breast Cancer Res. 2009 ;11(6):111. Epub 2009 Nov 26 .

PubMed
Biomarkers for epithelial-mesenchymal transitions.
Biomarkers for epithelial-mesenchymal transitions.
J Clin Invest. 2009 Jun ;119(6):1429-37. doi: 10.1172/JCI36183. Epub 2009 Jun 1 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...

You are here: NCBI > Literature > PubMed

Write to the Help Desk