Genome Med. 2009 Jan 22;1(1):12.

Variants in the ATM gene and breast cancer susceptibility.

Source

Genetic & Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain.

Abstract

It has been established that heterozygous carriers of ataxia-telangiectasia-causing mutations in the ATM gene are at approximately two-fold higher risk of breast cancer. Several studies have attempted to assess the potential implication of the gene's more common variants in breast cancer susceptibility. Three large case-control studies have consistently found no evidence of association for variants with minor allele frequency greater than 5%. Other studies have evaluated associations for coding variants with intermediate frequency (1-5%), but the results are inconsistent. Larger and/or combined association studies are needed to clarify this issue.

PMID:: 19348699; [PubMed]
PMCID: PMC2651585

Free PMC Article

LinkOut - more resources

Full Text Sources

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Final Report on Carcinogens Background Document for Styrene. [Rep Carcinog Backgr Doc. 2008]
Final Report on Carcinogens Background Document for Styrene.
National Toxicology Program. Rep Carcinog Backgr Doc. 2008 Sep; (8-5978):i-398.
Final Report on Carcinogens Background Document for Formaldehyde. [Rep Carcinog Backgr Doc. 2010]
Final Report on Carcinogens Background Document for Formaldehyde.
National Toxicology Program. Rep Carcinog Backgr Doc. 2010 Jan; (10-5981):i-512.
Identification of germline missense mutations and rare allelic variants in the ATM gene in early-onset breast cancer. [Genes Chromosomes Cancer. 1999]
Identification of germline missense mutations and rare allelic variants in the ATM gene in early-onset breast cancer.
Izatt L, Greenman J, Hodgson S, Ellis D, Watts S, Scott G, Jacobs C, Liebmann R, Zvelebil MJ, Mathew C, et al. Genes Chromosomes Cancer. 1999 Dec; 26(4):286-94.
Review Cancer risk in ATM heterozygotes: a model of phenotypic and mechanistic differences between missense and truncating mutations. [Mol Genet Metab. 1999]
Review Cancer risk in ATM heterozygotes: a model of phenotypic and mechanistic differences between missense and truncating mutations.
Gatti RA, Tward A, Concannon P. Mol Genet Metab. 1999 Dec; 68(4):419-23.
Review Inherited breast and ovarian cancer. [Hum Mol Genet. 1995]
Review Inherited breast and ovarian cancer.
Szabo CI, King MC. Hum Mol Genet. 1995; 4 Spec No:1811-7.

See reviews... See all...

Cited by 2 PubMed Central articles

The association between ATM D1853N polymorphism and breast cancer susceptibility: a meta-analysis. [J Exp Clin Cancer Res. 2010]
The association between ATM D1853N polymorphism and breast cancer susceptibility: a meta-analysis.
Gao LB, Pan XM, Sun H, Wang X, Rao L, Li LJ, Liang WB, Lv ML, Yang WZ, Zhang L. J Exp Clin Cancer Res. 2010 Aug 27; 29:117. Epub 2010 Aug 27.
Review Genetic determinants at the interface of cancer and neurodegenerative disease. [Oncogene. 2010]
Review Genetic determinants at the interface of cancer and neurodegenerative disease.
Morris LG, Veeriah S, Chan TA. Oncogene. 2010 Jun 17; 29(24):3453-64. Epub 2010 Apr 26.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
SNP (Cited)
Nucleotide polymorphism records from dbSNP that have NCBI dbSNP identifiers reported in the PubMed abstract of the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
SNP
Nucleotide polymorphism records from dbSNP that have current articles as submitter-provided references.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Variants in the ATM gene and breast cancer susceptibility.
Variants in the ATM gene and breast cancer susceptibility.
Genome Med. 2009 Jan 22 ;1(1):12.

PubMed
A new strategic phase for genomic medicine in UK health services.
A new strategic phase for genomic medicine in UK health services.
Genome Med. 2009 Oct 12 ;1(10):93.

PubMed
Predictive biomarker discovery through the parallel integration of clinical tria...
Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets.
Genome Med. 2010 Aug 11 ;2(8):53.

PubMed
Estrogen plus progestin and the risk of coronary heart disease.
Estrogen plus progestin and the risk of coronary heart disease.
N Engl J Med. 2003 Aug 7 ;349(6):523-34.

PubMed
Translational bioinformatics in the cloud: an affordable alternative.
Translational bioinformatics in the cloud: an affordable alternative.
Genome Med. 2010 Aug 6 ;2(8):51.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Variants in the ATM gene and breast cancer susceptibility.

Source

Abstract

LinkOut - more resources

Full Text Sources

Libraries

Supplemental Content

Related citations

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information