Curr Opin Cell Biol. 2009 Jun;21(3):426-34. Epub 2009 Mar 19.

RNA silencing in germlines--exquisite collaboration of Argonaute proteins with small RNAs for germline survival.

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Keio University School of Medicine, Tokyo 160-8582, Japan. siomim@sc.itc.keio.ac.jp

Abstract

As the proper development of germlines is vital for species preservation, elaborative, regulatory systems for gene expression must operate in germlines. One such system is RNA silencing, sequence-specific gene silencing mechanisms mediated by small RNAs of 20-30 nucleotides long. Indeed, recent studies have revealed that various types of small RNAs are expressed germline-specifically. To preserve the germlines, they collaborate with Argonaute proteins, the catalytic engines in RNA silencing, to inhibit injurious, parasitic genes, transcriptionally or post-transcriptionally. This chapter summarizes the exquisite collaboration of Argonaute proteins with small RNAs in the RNA silencing mechanisms necessary for germline survival in Drosophila and mice.

PMID:: 19303759; [PubMed - indexed for MEDLINE]

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