Arthritis Rheum. 1991 Sep;34(9):1158-63.

Correlation of serum interleukin-6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis.

de Benedetti F, Massa M, Robbioni P, Ravelli A, Burgio GR, Martini A.

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Universita' di Pavia, IRCCS Policlinico S. Matteo, Italy.

Abstract

We measured interleukin-6 (IL-6) levels in 70 serum samples obtained from 25 patients with systemic-onset juvenile rheumatoid arthritis (JRA), using the hybridoma cell line B9. Patients with systemic-onset JRA had significantly elevated serum IL-6 levels during active disease (mean +/- SD 92.1 +/- 75.1 hybridoma growth factor units/ml; P less than 0.00001 versus healthy age-matched controls), but not during remission. Serum IL-6 levels correlated with the extent and severity of joint involvement (P less than 0.001) and with platelet counts (P less than 0.05). Our data suggest that IL-6 plays a significant role in the pathogenesis of systemic-onset JRA.

Comment in

Arthritis Rheum. 1992 Jul;35(7):840.

PMID:: 1930333; [PubMed - indexed for MEDLINE]

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Research Support, Non-U.S. Gov't

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Interleukin-6

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