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    Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):9267-71.

    Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor.

    Maglione D, Guerriero V, Viglietto G, Delli-Bovi P, Persico MG.

    Source

    International Institute of Genetics and Biophysics, Consiglio Nazionale della Ricerce, Naples, Italy.

    Abstract

    A human cDNA coding for a protein related to the vascular permeability factor (VPF) was isolated from a term placenta cDNA library; we therefore named its product placenta growth factor (PlGF). PlGF is a 149-amino-acid-long protein and is highly homologous (53% identity) to the platelet-derived growth factor-like region of human VPF. Computer analyses reveal a putative signal peptide and two probable N-glycosylation sites in the PlGF protein, one of which is also conserved in human VPF. By using N-glycosidase F, tunicamycin, and specific antibodies produced in both chicken and rabbit, we demonstrate that PlGF, derived from transfected COS-1 cells, is actually N-glycosylated and secreted into the medium. In addition, PlGF, like VPF, proves to be a dimeric protein. Finally, a conditioned medium from COS-1 cells containing PlGF is capable of stimulating specifically the growth of CPA, a line of endothelial cells, in vitro.

    PMID:
    1924389
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC52695
    Free PMC Article

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