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    EMBO J. 1991 Oct;10(10):2839-48.

    Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130.

    Gearing DP, Thut CJ, VandeBos T, Gimpel SD, Delaney PB, King J, Price V, Cosman D, Beckmann MP.

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    Immunex Corporation, Seattle, WA 98101.

    Abstract

    Leukemia inhibitory factor (LIF) is a cytokine with a broad range of activities that in many cases parallel those of interleukin-6 (IL-6) although LIF and IL-6 appear to be structurally unrelated. A cDNA clone encoding the human LIF receptor was isolated by expression screening of a human placental cDNA library. The LIF receptor is related to the gp130 'signal-transducing' component of the IL-6 receptor and to the G-CSF receptor, with the transmembrane and cytoplasmic regions of the LIF receptor and gp130 being most closely related. This relationship suggests a common signal transduction pathway for the two receptors and may help to explain similar biological effects of the two ligands. Murine cDNAs encoding soluble LIF receptors were isolated by cross-hybridization and share 70% amino acid sequence identity to the human sequence.

    PMID:
    1915266
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC452994
    Free PMC Article

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