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    Antimicrob Agents Chemother. 2009 Mar;53(3):1231-4. Epub 2009 Jan 5.

    Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus.

    Cui L, Neoh HM, Shoji M, Hiramatsu K.

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    Department of Bacteriology, Faculty of Medicine, Juntendo University, Tokyo, Japan. longzhu@juntendo.ac.jp

    Abstract

    We describe here the genetic analysis of a vancomycin-susceptible Staphylococcus aureus (VSSA) strain, Mu50Omega, a strain related to vancomycin-intermediate S. aureus (VISA) strain Mu50. Using a combination of Mu50Omega whole-genome sequencing and genome engineering, we observed a stepwise evolution of vancomycin resistance from VSSA to VISA after the mutated vraS and graR genes of Mu50 were engineered into Mu50Omega.

    PMID:
    19124662
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2650561
    Free PMC Article

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