Biol Psychiatry. 1991 Aug 15;30(4):371-6.

The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs: a preliminary study.

MacFarlane JG, Cleghorn JM, Brown GM, Streiner DL.

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Faculty of Health Sciences, McMaster University.

Abstract

The effects of exogenous, supraphysiologic doses of melatonin on the total sleep time and daytime alertness of patients with chronic insomnia was examined in a double blind, single crossover study. Melatonin (75 mg per os) or identical placebo was administered at 10 PM daily to 13 insomniac patients for 14 consecutive days. A significant increase in the subjective assessment of total sleep time and daytime alertness was demonstrated with melatonin but not with placebo. However, 7 of the 13 patients reported that the active treatment had no significant effect on subjective feelings of well-being.

PMID:: 1912128; [PubMed - indexed for MEDLINE]

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