J Negat Results Biomed. 2008 Dec 16;7:12.

Host factors do not influence the colonization or infection by fluconazole resistant Candida species in hospitalized patients.

Yang YL, Cheng MF, Chang YW, Young TG, Chi H, Lee SC, Cheung BM, Tseng FC, Chen TC, Ho YH, Shi ZY, Chan CH, Lin JY, Lo HJ.

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Division of Clinical Research, National Health Research Institutes, Miaoli, Taiwan, Republic of China. yyang@mail.nctu.edu.tw

Abstract

Nosocomial yeast infections have significantly increased during the past two decades in industrialized countries, including Taiwan. This has been associated with the emergence of resistance to fluconazole and other antifungal drugs. The medical records of 88 patients, colonized or infected with Candida species, from nine of the 22 hospitals that provided clinical isolates to the Taiwan Surveillance of Antimicrobial Resistance of Yeasts (TSARY) program in 1999 were reviewed. A total of 35 patients contributed fluconazole resistant strains [minimum inhibitory concentrations (MICs) > or = 64 mg/l], while the remaining 53 patients contributed susceptible ones (MICs < or = 8 mg/l). Fluconazole resistance was more frequent among isolates of Candida tropicalis (46.5%) than either C. albicans (36.8%) or C. glabrata (30.8%). There was no significant difference in demographic characteristics or underlying diseases among patients contributing strains different in drug susceptibility.

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PMCID:: PMC2621115

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Host factors do not influence the colonization or infection by fluconazole resistant Candida species in hospitalized patients.

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