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    Nature. 1991 Jun 6;351(6326):456-60.

    New use of BCG for recombinant vaccines.

    Source

    MedImmune Incorporated, Gaithersburg, Maryland 20878.

    Abstract

    BCG, a live attenuated tubercle bacillus, is the most widely used vaccine in the world and is also a useful vaccine vehicle for delivering protective antigens of multiple pathogens. Extrachromosomal and integrative expression vectors carrying the regulatory sequences for major BCG heat-shock proteins have been developed to allow expression of foreign antigens in BCG. These recombinant BCG strains can elicit long-lasting humoral and cellular immune responses to foreign antigens in mice.

    PMID:
    1904554
    [PubMed - indexed for MEDLINE]

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