Biochem Soc Trans. 2008 Dec;36(Pt 6):1384-8.

Nuclear motors and nuclear structures containing A-type lamins and emerin: is there a functional link?

Mehta IS, Elcock LS, Amira M, Kill IR, Bridger JM.

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Division of Biosciences, Laboratory of Nuclear and Genomic Health, Centre for Cell and Chromosome Biology, School of Health Sciences and Social Care, Brunel University, Uxbridge, UK.

Abstract

Rapid interphase chromosome territory repositioning appears to function through the action of nuclear myosin and actin, in a nuclear motor complex. We have found that chromosome repositioning when cells leave the cell cycle is not apparent in cells that have mutant lamin A or that are lacking emerin. We discuss the possibility that there is a functional intranuclear complex comprising four proteins: nuclear actin, lamin A, emerin and nuclear myosin. If any of the components are lacking or aberrant, then the nuclear motor complex involved in moving chromosomes or genes will be dysfunctional, leading to an inability to move chromosomes in response to signalling events.

PMID:: 19021560; [PubMed - indexed for MEDLINE]

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