Arthritis Res Ther. 2008;10(5):121. Epub 2008 Oct 31.

High-density lipoprotein: does it have a dark side?

Abstract

There are proven pleiotropic anti-atherogenic actions of high-density lipoprotein (HDL). However, in systemic inflammation, HDL can have pro-inflammatory properties that may contribute to accelerated atherosclerosis, likely mediated by a change in the structure of HDL to pro-inflammatory HDL (PiHDL). Validation of the technically challenging assay for PiHDL, and confirmation of an association of PiHDL in multiple populations with known risk for atherosclerosis will eventually provide a useful biomarker. Identification of PiHDL in patients with rheumatic disease may help identify patients at risk of accelerated atherosclerosis, and focus our therapeutic interventions.

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Arthritis Res Ther. 2008;10(4):213.

PMID:: 19014411; [PubMed - indexed for MEDLINE]
PMCID: PMC2592810

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Lipoproteins, HDL

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