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    Immunogenetics. 2009 Jan;61(1):55-70. Epub 2008 Nov 14.

    Non-coding RNAs revealed during identification of genes involved in chicken immune responses.

    Ahanda ML, Ruby T, Wittzell H, Bed'Hom B, Chaussé AM, Morin V, Oudin A, Chevalier C, Young JR, Zoorob R.

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    CNRS, FRE2937, 7 rue Guy Moquet, F-94800, Villejuif, France. endale@vjf.cnrs.fr

    Abstract

    Recent large-scale cDNA cloning studies have shown that a significant proportion of the transcripts expressed from vertebrate genomes do not appear to encode protein. Moreover, it was reported in mammals (human and mice) that these non-coding transcripts are expressed and regulated by mechanisms similar to those involved in the control of protein-coding genes. We have produced a collection of cDNA sequences from immunologically active tissues with the aim of discovering chicken genes involved in immune mechanisms, and we decided to explore the non-coding component of these immune-related libraries. After finding known non-coding RNAs (miRNA, snRNA, snoRNA), we identified new putative mRNA-like non-coding RNAs. We characterised their expression profiles in immune-related samples. Some of them showed changes in expression following viral infections. As they exhibit patterns of expression that parallel the behaviour of protein-coding RNAs in immune tissues, our study suggests that they could play an active role in the immune response.

    PMID:
    19009289
    [PubMed - indexed for MEDLINE]

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