J Neural Transm. 2009 Aug;116(8):983-7. Epub 2008 Nov 11.

Neurotransmitter receptor heteromers in neurodegenerative diseases and neural plasticity.

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Department of Biochemistry and Molecular Biology, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Institut d'Investigació Biomèdica August Pi i Sunyer, University of Barcelona, Barcelona, Spain. rfranco@unav.es

Abstract

Metabotropic receptors for neurotransmitters on the plasma membrane of neurons are forming homo- hetero- dimers and even homo- or hetero-oligomers. Neurotransmission has been studied assuming that these G-protein-coupled receptors were monomers. Then, on considering receptor dimers, we are entering a new era for the understanding how neurotransmitter receptors decode signals originating at the nervous system. At the moment it is becoming clear that receptor homo and hetero-oligomers provide signaling diversity, help to understand synaptic plasticity and open new therapeutic potential as targets for neurodegenerative and neuropsychiatric diseases.

PMID:: 19002553; [PubMed - indexed for MEDLINE]

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Neurotransmitter receptor heteromers in neurodegenerative diseases and neural plasticity.

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