Cell. 2008 Oct 31;135(3):417-20.

Knockdown screens to knockout HIV-1.

Source

Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, HHSC 1310c, New York, NY 10032, USA. spg1@columbia.edu

Abstract

Three recent screens use siRNAs to identify host genes that are critical for HIV-1 replication. These screens have uncovered hundreds of human genes not previously known to be commandeered by the virus during infection. Although some caveats remain, this screening approach opens up a new landscape of viral-host interactions for future exploration.

PMID:: 18984154; [PubMed - indexed for MEDLINE]

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