Arthritis Res Ther. 2008;10(5):225. Epub 2008 Oct 17.

Immune regulation of bone loss by Th17 cells.

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Department of Immunology, Schering Plough Biopharma, 901 California Avenue, Palo Alto, CA 94304, USA. iannis.adamopoulos@spcorp.com

Abstract

A significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines produced by activated macrophages and T cells are implicated in arthritis pathogenesis and are involved in osteoclast-mediated bone resorption. The scope of the present review is to analyze current knowledge and to provide a better understanding of how macrophage-derived factors promote the differentiation of a novel T-helper subset (Th17) that promotes osteoclast formation and activation.

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PMCID: PMC2592787

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