Genome Biol. 2008;9(9):232. Epub 2008 Sep 18.

The telosome/shelterin complex and its functions.

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Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Baylor Plaza, Houston, TX 77030, USA.

Abstract

The telomeres that cap the ends of eukaryotic chromosomes serve a dual role in protecting the chromosome ends and in intracellular signaling for regulating cell proliferation. A complex of six telomere-associated proteins has been identified--the telosome or shelterin complex--that is crucial for both the maintenance of telomere structure and its signaling functions.

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PMCID: PMC2592706

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Telomere-Binding Proteins

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