Retrovirology. 2008 Sep 22;5:85.

How to engage Cofilin.

Source

George Washington University, Department of Microbiology, Immunology and Tropical Medicine, Washington, DC 20037, USA. mtmmib@gwumc.edu

Abstract

In HIV-infected people, resting CD4+ T cells are the main reservoir of latent virus and the reason for the failure of drug therapy to cure HIV infection. Still, we do not have a complete understanding of the factors regulating HIV replication in these cells. A recent paper in Cell describes a new trick that the virus uses to infect resting T cells. Interaction between the viral gp120 and cellular HIV co-receptor, CXCR4, during viral entry initiates signaling that activates cofilin, the main regulator of actin polymerization. As a result of this activation, actin is depolymerized, thus destroying the natural barrier to HIV replication. I discuss implications of this study for our understanding of HIV biology and development of novel anti-HIV therapeutic approaches.

PMID:: 18808680; [PubMed - indexed for MEDLINE]
PMCID: PMC2567344

Free PMC Article

Images from this publication.See all images (1) Free text

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

Cofilin 1

LinkOut - more resources

Full Text Sources

Other Literature Sources

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients: a pilot study. [Retrovirology. 2008]
Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients: a pilot study.
Wu Y, Yoder A, Yu D, Wang W, Liu J, Barrett T, Wheeler D, Schlauch K. Retrovirology. 2008 Oct 17; 5:95. Epub 2008 Oct 17.
HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells. [Cell. 2008]
HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells.
Yoder A, Yu D, Dong L, Iyer SR, Xu X, Kelly J, Liu J, Wang W, Vorster PJ, Agulto L, et al. Cell. 2008 Sep 5; 134(5):782-92.
Chemokine receptor signaling and HIV infection. [Methods Mol Biol. 2009]
Chemokine receptor signaling and HIV infection.
Wu Y. Methods Mol Biol. 2009; 571:309-19.
Review [Potential of integrase inhibitors to deplete HIV reservoirs or prevent their replenishment]. [Enferm Infecc Microbiol Clin. 2008]
Review [Potential of integrase inhibitors to deplete HIV reservoirs or prevent their replenishment].
Llibre JM, Martínez-Picado J. Enferm Infecc Microbiol Clin. 2008 Nov; 26 Suppl 12:17-22.
Review Endocytosis of HIV: anything goes. [Trends Microbiol. 2010]
Review Endocytosis of HIV: anything goes.
Permanyer M, Ballana E, Esté JA. Trends Microbiol. 2010 Dec; 18(12):543-51. Epub 2010 Oct 19.

See reviews... See all...

Cited by 3 PubMed Central articles

LIM kinase 1 - dependent cofilin 1 pathway and actin dynamics mediate nuclear retinoid receptor function in T lymphocytes. [BMC Mol Biol. 2011]
LIM kinase 1 - dependent cofilin 1 pathway and actin dynamics mediate nuclear retinoid receptor function in T lymphocytes.
Ishaq M, Lin BR, Bosche M, Zheng X, Yang J, Huang D, Lempicki RA, Natarajan V. BMC Mol Biol. 2011 Sep 16; 12:41. Epub 2011 Sep 16.
Review Recent advances in lentiviral vector development and applications. [Mol Ther. 2010]
Review Recent advances in lentiviral vector development and applications.
Mátrai J, Chuah MK, VandenDriessche T. Mol Ther. 2010 Mar; 18(3):477-90. Epub 2010 Jan 19.
Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients: a pilot study. [Retrovirology. 2008]
Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients: a pilot study.
Wu Y, Yoder A, Yu D, Wang W, Liu J, Barrett T, Wheeler D, Schlauch K. Retrovirology. 2008 Oct 17; 5:95. Epub 2008 Oct 17.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

How to engage Cofilin.
How to engage Cofilin.
Retrovirology. 2008 Sep 22 ;5:85.

PubMed
The origins of acquired immune deficiency syndrome viruses: where and when?
The origins of acquired immune deficiency syndrome viruses: where and when?
Philos Trans R Soc Lond B Biol Sci. 2001 Jun 29 ;356(1410):867-76.

PubMed
Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the...
Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein.
Nature. 2002 Aug 8 ;418(6898):646-50. Epub 2002 Jul 14 .

PubMed
Viral load and heterosexual transmission of human immunodeficiency virus type 1....
Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group.
N Engl J Med. 2000 Mar 30 ;342(13):921-9.

PubMed
Oxidative stress and the pathogenesis of neurodegenerative disorders.
Oxidative stress and the pathogenesis of neurodegenerative disorders.
Int Rev Neurobiol. 2007 ;82:297-325.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: