Cell. 1991 Aug 23;66(4):759-68.

A novel poly(A)-binding protein acts as a specificity factor in the second phase of messenger RNA polyadenylation.

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Department of Cell Biology, Biozentrum, Universität Basel, Switzerland.

Erratum in

Cell 1991 Nov 1;67(3):following 639.

Abstract

Polyadenylation of mRNA precursors by poly(A) polymerase depends on a specificity factor, CPF, recognizing the polyadenylation signal AAUAAA. This paper describes an apparently novel poly(A)-binding protein that acts as a second specificity factor, mediating the recognition of the growing poly(A) tail. A transition from a slow initiation phase of polyadenylation to rapid elongation occurs when the growing tail is long enough to serve as a binding site for the poly(A)-binding protein. Elongation of an RNA carrying a tail of 10 or more adenylate residues can occur independently of CPF. A sharp decrease in the poly(A) chain growth rate after the addition of approximately 200 adenylate residues invites speculations about a role of the poly(A)-binding protein in poly(A) tail length control.

PMID:: 1878970; [PubMed - indexed for MEDLINE]

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Assembly of a processive messenger RNA polyadenylation complex. [EMBO J. 1993]
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Bienroth S, Keller W, Wahle E. EMBO J. 1993 Feb; 12(2):585-94.
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