Adv Enzyme Regul. 1991;31:121-81.

Patterns of divergence in homologous proteins as indicators of secondary and tertiary structure: a prediction of the structure of the catalytic domain of protein kinases.

Source

Laboratory for Organic Chemistry, E.T.H., Zurich, Switzerland.

Abstract

The secondary structure and elements of tertiary structure have been predicted for the catalytic domain of protein kinases using a method that extracts structural information from the patterns of conservation and variation in an alignment of homologous proteins. The central features of this structural prediction are: (a) the catalytic domains of protein kinases do not incorporate a Rossmann fold; (b) the core of the structure is founded on beta sheets built from pairs of bent antiparallel beta strands; (c) five helices, including an especially long helix (alignment positions 129-152) that lie on the outside of the folded core. These proteins are important in many aspects of metabolic regulation.

PMID:: 1877385; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Protein Kinases

LinkOut - more resources

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

A consensus prediction of the secondary structure for the 6-phospho-beta-D-galactosidase superfamily. [Proteins. 1995]
A consensus prediction of the secondary structure for the 6-phospho-beta-D-galactosidase superfamily.
Gerloff DL, Benner SA. Proteins. 1995 Apr; 21(4):273-81.
Analysis on sliding helices and strands in protein structural comparisons: a case study with protein kinases. [J Biosci. 2007]
Analysis on sliding helices and strands in protein structural comparisons: a case study with protein kinases.
Gowri VS, Anamika K, Gore S, Srinivasan N. J Biosci. 2007 Aug; 32(5):921-8.
Review Predicting the conformation of proteins from sequences. Progress and future progress. [J Mol Recognit. 1995]
Review Predicting the conformation of proteins from sequences. Progress and future progress.
Benner SA. J Mol Recognit. 1995 Jan-Apr; 8(1-2):9-28.
The refined crystal structure of Bacillus cereus oligo-1,6-glucosidase at 2.0 A resolution: structural characterization of proline-substitution sites for protein thermostabilization. [J Mol Biol. 1997]
The refined crystal structure of Bacillus cereus oligo-1,6-glucosidase at 2.0 A resolution: structural characterization of proline-substitution sites for protein thermostabilization.
Watanabe K, Hata Y, Kizaki H, Katsube Y, Suzuki Y. J Mol Biol. 1997 May 30; 269(1):142-53.
Review Protein kinases share a common structural motif outside the conserved catalytic domain. [Cell Mol Biol (Noisy-le-grand)...]
Review Protein kinases share a common structural motif outside the conserved catalytic domain.
Véron M, Radzio-Andzelm E, Tsigelny I, Taylor S. Cell Mol Biol (Noisy-le-grand). 1994 Jul; 40(5):587-96.

See reviews... See all...

Cited by 17 PubMed Central articles

A novel protein kinase-like domain in a selenoprotein, widespread in the tree of life. [PLoS One. 2012]
A novel protein kinase-like domain in a selenoprotein, widespread in the tree of life.
Dudkiewicz M, Szczepińska T, Grynberg M, Pawłowski K. PLoS One. 2012; 7(2):e32138. Epub 2012 Feb 16.
Genome-wide influence of indel Substitutions on evolution of bacteria of the PVC superphylum, revealed using a novel computational method. [Genome Biol Evol. 2010]
Genome-wide influence of indel Substitutions on evolution of bacteria of the PVC superphylum, revealed using a novel computational method.
Kamneva OK, Liberles DA, Ward NL. Genome Biol Evol. 2010; 2:870-86. Epub 2010 Nov 3.
Mining protein loops using a structural alphabet and statistical exceptionality. [BMC Bioinformatics. 2010]
Mining protein loops using a structural alphabet and statistical exceptionality.
Regad L, Martin J, Nuel G, Camproux AC. BMC Bioinformatics. 2010 Feb 4; 11:75. Epub 2010 Feb 4.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Patterns of divergence in homologous proteins as indicators of secondary and ter...
Patterns of divergence in homologous proteins as indicators of secondary and tertiary structure: a prediction of the structure of the catalytic domain of protein kinases.
Adv Enzyme Regul. 1991 ;31:121-81.

PubMed
Gating-ML: XML-based gating descriptions in flow cytometry.
Gating-ML: XML-based gating descriptions in flow cytometry.
Cytometry A. 2008 Dec ;73A(12):1151-7.

PubMed
Identification of Ets- and notch-related subunits in GA binding protein.
Identification of Ets- and notch-related subunits in GA binding protein.
Science. 1991 Aug 16 ;253(5021):789-92.

PubMed
Elemental selenium particles at nano-size (Nano-Se) are more toxic to Medaka (Or...
Elemental selenium particles at nano-size (Nano-Se) are more toxic to Medaka (Oryzias latipes) as a consequence of hyper-accumulation of selenium: a comparison with sodium selenite.
Aquat Toxicol. 2008 Sep 29 ;89(4):251-6. Epub 2008 Jul 25 .

PubMed
Problems induced by meta-analyses.
Problems induced by meta-analyses.
Stat Med. 1991 Jun ;10(6):971-9; discussion 979-80.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: