J Biol Chem. 1991 Aug 25;266(24):15999-606.

Deficient protein kinase C activity in turnip, a Drosophila learning mutant.

Choi KW, Smith RF, Buratowski RM, Quinn WG.

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Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139.

Abstract

The Drosophila mutant turnip was initially isolated based on poor learning performance (Quinn, W.G., Sziber, P.P., and Booker, R. (1979) Nature 277, 212-214). Here we show that turnip is dramatically reduced in protein kinase C (PKC) activity. In addition, turnip flies are deficient in phosphorylation of a 76-kDa head membrane protein (hereafter pp76) which is a major substrate for protein kinase C in homogenates of wild-type flies. Reduced PKC activity, defective pp76 phosphorylation, and most of turnip's learning deficiency co-map genetically to a region on the X-chromosome, 18A5-18D1-2, spanned by the deletion Df(1)JA27. Apparently turnip+ is not a structural gene for PKC because Drosophila PKC genes map elsewhere in the genome. Our results suggest that turnip gene product is required for activation of PKC and that PKC plays a role in associative learning in Drosophila.

PMID:: 1874743; [PubMed - indexed for MEDLINE]

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