Bol Med Hosp Infant Mex. 1991 Apr;48(4):230-4.

[The quantitative analysis of thyroid hormones and thyrotropin in children critically ill with septicemia].

[Article in Spanish]

Mendoza-Morfín F, Vaca-Arellano MR, Toledo-Villalpando AD, Olvera-Hidalgo C, Mondragón-Rosales L, Junco-Lorenzana E.

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Departamento de Endocrinología Pediátrica, Hospital General, Centro Médico La Raza, México, D.F.

Abstract

The function of the hypothalamus, hypophysis, and thyroid glands was studied in 23 critically-ill septicemic children and 15 other healthy children used as controls. A comparison in the quantification of 3,3'5-triiodothyronine (T3), 3,3',5'triiodothyronine (T3r), thyroxine (T4) and thyrotropin (TSH) from those in the control group with the initial values from the patients showed a notable decrease of T3 and T4 and a rise in T3r and TSH in the septicemic children, with a statistical significant difference (P less than 0.001). These biochemical changes which translate into a homeostatic command to avoid catabolism through the conservation of energy, spontaneously returned to normal in 18 of the surviving septicemic children once they recuperated.

PMID:: 1867742; [PubMed - indexed for MEDLINE]

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Cited by 1 PubMed Central article

Rest energy expenditure is decreased during the acute as compared to the recovery phase of sepsis in newborns. [Nutr Metab (Lond). 2010]
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Feferbaum R, Leone C, Siqueira AA, Valenti VE, Gallo PR, Reis AO, Lopes AC, Nascimento VG, de Oliveira AG, de Carvalho TD, et al. Nutr Metab (Lond). 2010 Jul 23; 7:63. Epub 2010 Jul 23.

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