Breast Cancer Res. 2008;10(4):211. Epub 2008 Jul 24.

Molecular targeted therapies for breast cancer treatment.

Schlotter CM, Vogt U, Allgayer H, Brandt B.

Source

Department of Obstetrics and Gynecology, Breast Centre Klinikum Lüdenscheid, Academic Teaching Hospital of the University Bonn, Luedenscheid, Paulmannshoeher Str, 14 - 58515 Luedenscheid Germany.

Abstract

Targeting the oestrogen receptor, HER2 (human epidermal growth factor receptor 2) and vascular endothelial growth factor has markedly improved breast cancer therapy. New targeted therapeutic approaches to induction of apoptosis or inhibition of anti-apoptosis, cell cycle progression, signal transduction and angiogenesis are described. The molecular pathways and their inhibitory or repair mechanisms are discussed in the preclinical and clinical settings.

PMID:: 18671839; [PubMed - indexed for MEDLINE]
PMCID:: PMC2575526

Free PMC Article

Images from this publication.See all images (1) Free text

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Review Linkage between EGFR family receptors and nuclear factor kappaB (NF-kappaB) signaling in breast cancer. [J Cell Physiol. 2006]
Review Linkage between EGFR family receptors and nuclear factor kappaB (NF-kappaB) signaling in breast cancer.
Biswas DK, Iglehart JD. J Cell Physiol. 2006 Dec; 209(3):645-52.
Epidermal growth factor receptor as a potential therapeutic target in triple-negative breast cancer. [Ann Oncol. 2009]
Epidermal growth factor receptor as a potential therapeutic target in triple-negative breast cancer.
Corkery B, Crown J, Clynes M, O'Donovan N. Ann Oncol. 2009 May; 20(5):862-7. Epub 2009 Jan 15.
Review Interactions between estrogen and growth factor receptors in human breast cancers and the tumor-associated vasculature. [Breast J. 2003]
Review Interactions between estrogen and growth factor receptors in human breast cancers and the tumor-associated vasculature.
Pietras RJ. Breast J. 2003 Sep-Oct; 9(5):361-73.
Review Molecular approach to breast cancer treatment. [Semin Oncol. 2004]
Review Molecular approach to breast cancer treatment.
Yarden Y, Baselga J, Miles D. Semin Oncol. 2004 Oct; 31(5 Suppl 10):6-13.
Review The new generation of targeted therapies for breast cancer. [Oncology (Williston Park). 2003]
Review The new generation of targeted therapies for breast cancer.
Syed S, Rowinsky E. Oncology (Williston Park). 2003 Oct; 17(10):1339-51; discussion 1352, 1355-6.

See reviews... See all...

Cited by 4 PubMed Central articles

A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone. [BMC Cancer. 2011]
A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone.
Altenburg JD, Bieberich AA, Terry C, Harvey KA, Vanhorn JF, Xu Z, Jo Davisson V, Siddiqui RA. BMC Cancer. 2011 Apr 21; 11:149. Epub 2011 Apr 21.
Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer. [Cancer Res. 2010]
Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer.
Pond AC, Herschkowitz JI, Schwertfeger KL, Welm B, Zhang Y, York B, Cardiff RD, Hilsenbeck S, Perou CM, Creighton CJ, et al. Cancer Res. 2010 Jun 15; 70(12):4868-79. Epub 2010 May 25.
Estrogen suppresses MLK3-mediated apoptosis sensitivity in ER+ breast cancer cells. [Cancer Res. 2010]
Estrogen suppresses MLK3-mediated apoptosis sensitivity in ER+ breast cancer cells.
Rangasamy V, Mishra R, Mehrotra S, Sondarva G, Ray RS, Rao A, Chatterjee M, Rana B, Rana A. Cancer Res. 2010 Feb 15; 70(4):1731-40. Epub 2010 Feb 9.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Molecular targeted therapies for breast cancer treatment.
Molecular targeted therapies for breast cancer treatment.
Breast Cancer Res. 2008 ;10(4):211. Epub 2008 Jul 24 .

PubMed
Truncated forms of DNA-binding estrogen receptors in human breast cancer.
Truncated forms of DNA-binding estrogen receptors in human breast cancer.
J Clin Invest. 1991 Aug ;88(2):700-6.

PubMed
BRCA1 mutations in Algerian breast cancer patients: high frequency in young, spo...
BRCA1 mutations in Algerian breast cancer patients: high frequency in young, sporadic cases.
Int J Med Sci. 2008 Jul 8 ;5(4):197-202.

PubMed
Inhibition of c-myc expression by phosphorothioate antisense oligonucleotide ide...
Inhibition of c-myc expression by phosphorothioate antisense oligonucleotide identifies a critical role for c-myc in the growth of human breast cancer.
Cancer Res. 1991 Aug 1 ;51(15):3996-4000.

PubMed
Promoter methylation of p16 and EDNRB gene in leukemia patients in Taiwan.
Promoter methylation of p16 and EDNRB gene in leukemia patients in Taiwan.
Chin J Physiol. 2008 Feb 29 ;51(1):27-31.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Molecular targeted therapies for breast cancer treatment.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 4 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information