Rheum Dis Clin North Am. 1991 May;17(2):323-32.

Dietary amino acid-induced systemic lupus erythematosus.

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Division of Allergy and Clinical Immunology, Oregon Health Sciences University, Portland.

Abstract

The effects of dietary manipulations on autoimmune disease are understood poorly. In this article, we detail our experience with a human subject who developed autoimmune hemolytic anemia while participating in a research study that required the ingestion of alfalfa seeds. Subsequent experimental studies in primates ingesting alfalfa sprout seeds and L-canavanine (a prominent amino acid constituent of alfalfa) is presented. The results of these studies indicate a potential toxic and immunoregulatory role of L-canavanine in the induction of a systemic lupus-like disease in primates.

PMID:: 1862241; [PubMed - indexed for MEDLINE]

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Systemic lupus erythematosus-like syndrome in monkeys fed alfalfa sprouts: role of a nonprotein amino acid. [Science. 1982]
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Malinow MR, Bardana EJ Jr, Pirofsky B, Craig S, McLaughlin P. Science. 1982 Apr 23; 216(4544):415-7.
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Effects of L-canavanine on T cells may explain the induction of systemic lupus erythematosus by alfalfa. [Arthritis Rheum. 1985]
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Alcocer-Varela J, Iglesias A, Llorente L, Alarcón-Segovia D. Arthritis Rheum. 1985 Jan; 28(1):52-7.
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