Dev Cell. 2008 Jul;15(1):11-22.

Signal-induced repression: the exception or the rule in developmental signaling?

Affolter M, Pyrowolakis G, Weiss A, Basler K.

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Biozentrum der Universität Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland. markus.affolter@unibas.ch

Abstract

Cell-cell communication plays a key role in organ formation and patterning in multicellular animals and is carried out by a few evolutionarily conserved signaling pathways. The modes of action of these pathways share a number of general properties, or habits, that allow them to strongly activate target genes in a ligand-dependent manner in the proper cellular contexts. Recent studies have revealed that some developmental signaling pathways can also strongly repress genes in a ligand-dependent manner. These new findings raise the interesting possibility that this repressive mode of action is shared by many or most developmental signaling pathways.

PMID:: 18606137; [PubMed - indexed for MEDLINE]

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