Br J Anaesth. 1991 Jul;67(1):41-8.

Pharmacokinetic model driven infusion of propofol in children.

Source

Division of Anaesthetics, Glasgow Royal Infirmary.

Abstract

A computer controlled infusion device for propofol was used to induce and maintain general anaesthesia in 20 children undergoing minor surgical procedures. The device was programmed with an adult pharmacokinetic model for propofol. During and after anaesthesia, blood samples were taken for measurement of propofol concentrations and it was found that the values obtained were systematically overpredicted by the delivery system algorithm. New pharmacokinetic microconstants were derived from our data which reflected more accurately the elimination and distribution of propofol in a prospective study involving another 10 children.

Comment in

Br J Anaesth. 1998 Sep;81(3):484.

PMID:: 1859758; [PubMed - indexed for MEDLINE]

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