Mol Biochem Parasitol. 1991 May;46(1):137-47.

The ring-infected erythrocyte surface antigen of Plasmodium falciparum associates with spectrin in the erythrocyte membrane.

Foley M, Tilley L, Sawyer WH, Anders RF.

Source

Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.

Abstract

The malaria parasite Plasmodium falciparum synthesises a protein, RESA, which associates with the membrane of newly invaded erythrocytes. Using spent supernatants from P. falciparum growing in culture as a source of soluble RESA we have developed an assay to examine the characteristics of RESA binding to the erythrocyte membrane in vitro. RESA associated with the Triton X-100 insoluble proteins on the inner face of the host erythrocyte membrane but did not bind to the outer surface of intact erythrocytes. Other proteins present in culture supernatants did not bind to the erythrocyte membrane. RESA was co-sedimented with the ternary complex formed between actin, spectrin and band 4.1 and co-precipitated with spectrin precipitated with anti-spectrin antibodies. The extent of association between RESA and the inner face of the erythrocyte membrane was reduced by the inclusion of excess purified spectrin in the assay. Thus, RESA appears to be associated with spectrin in the erythrocyte membrane skeleton.

PMID:: 1852169; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Elsevier Science

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Plasmodium falciparum: mapping the membrane-binding domain in the ring-infected erythrocyte surface antigen. [Exp Parasitol. 1994]
Plasmodium falciparum: mapping the membrane-binding domain in the ring-infected erythrocyte surface antigen.
Foley M, Corcoran L, Tilley L, Anders R. Exp Parasitol. 1994 Nov; 79(3):340-50.
The ring-infected erythrocyte surface antigen protein of Plasmodium falciparum is phosphorylated upon association with the host cell membrane. [Mol Biochem Parasitol. 1990]
The ring-infected erythrocyte surface antigen protein of Plasmodium falciparum is phosphorylated upon association with the host cell membrane.
Foley M, Murray LJ, Anders RF. Mol Biochem Parasitol. 1990 Jan 1; 38(1):69-75.
The Plasmodium falciparum protein RESA interacts with the erythrocyte cytoskeleton and modifies erythrocyte thermal stability. [Mol Biochem Parasitol. 1994]
The Plasmodium falciparum protein RESA interacts with the erythrocyte cytoskeleton and modifies erythrocyte thermal stability.
Da Silva E, Foley M, Dluzewski AR, Murray LJ, Anders RF, Tilley L. Mol Biochem Parasitol. 1994 Jul; 66(1):59-69.
Review Structure and function of candidate vaccine antigens in Plasmodium falciparum. [Biochem Soc Symp. 1987]
Review Structure and function of candidate vaccine antigens in Plasmodium falciparum.
Anders RF, Murray LJ, Thomas LM, Davern KM, Brown GV, Kemp DJ. Biochem Soc Symp. 1987; 53:103-14.
Review Structure and possible function of Plasmodium falciparum proteins exported to the erythrocyte membrane. [Parasitol Res. 1991]
Review Structure and possible function of Plasmodium falciparum proteins exported to the erythrocyte membrane.
Knapp B, Hundt E, Lingelbach KR. Parasitol Res. 1991; 77(4):277-82.

See reviews... See all...

Cited by 18 PubMed Central articles

Functional analysis of the exported type IV HSP40 protein PfGECO in Plasmodium falciparum gametocytes. [Eukaryot Cell. 2011]
Functional analysis of the exported type IV HSP40 protein PfGECO in Plasmodium falciparum gametocytes.
Morahan BJ, Strobel C, Hasan U, Czesny B, Mantel PY, Marti M, Eksi S, Williamson KC. Eukaryot Cell. 2011 Nov; 10(11):1492-503. Epub 2011 Sep 30.
A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray. [Proc Natl Acad Sci U S A. 2010]
A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray.
Crompton PD, Kayala MA, Traore B, Kayentao K, Ongoiba A, Weiss GE, Molina DM, Burk CR, Waisberg M, Jasinskas A, et al. Proc Natl Acad Sci U S A. 2010 Apr 13; 107(15):6958-63. Epub 2010 Mar 29.
Molecular cloning and characterisation of the RESA gene, a marker of genetic diversity of Plasmodium falciparum. [Mol Biol Rep. 2010]
Molecular cloning and characterisation of the RESA gene, a marker of genetic diversity of Plasmodium falciparum.
Moyano EM, González LM, Cuevas L, Perez-Pastrana E, Santa-Maria Y, Benito A. Mol Biol Rep. 2010 Jul; 37(6):2893-902. Epub 2009 Oct 9.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The ring-infected erythrocyte surface antigen of Plasmodium falciparum associate...
The ring-infected erythrocyte surface antigen of Plasmodium falciparum associates with spectrin in the erythrocyte membrane.
Mol Biochem Parasitol. 1991 May ;46(1):137-47.

PubMed
Cooperative role of macrophages and neutrophils in host Antiprotozoan resistance...
Cooperative role of macrophages and neutrophils in host Antiprotozoan resistance in mice acutely infected with Cryptosporidium parvum.
Infect Immun. 2008 Aug ;76(8):3657-63. Epub 2008 Jun 2 .

PubMed
Cloning of the Plasmodium vivax Duffy receptor.
Cloning of the Plasmodium vivax Duffy receptor.
Mol Biochem Parasitol. 1991 Jan ;44(1):125-32.

PubMed
A regulatable transgene expression system for cultured Plasmodium falciparum par...
A regulatable transgene expression system for cultured Plasmodium falciparum parasites.
Malar J. 2008 May 20 ;7:86.

PubMed
A physiological role for endogenous zinc in rat hippocampal synaptic neurotransm...
A physiological role for endogenous zinc in rat hippocampal synaptic neurotransmission.
Nature. 1991 Feb 7 ;349(6309):521-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

The ring-infected erythrocyte surface antigen of Plasmodium falciparum associates with spectrin in the erythrocyte membrane.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 18 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information