FEBS Lett. 1991 Apr 9;281(1-2):9-19.

DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian systems.

Source

Division of Pulmonary Medicine, UC Davis Medical Center, Sacramento 95817.

Abstract

When cells are exposed to oxidative stress, DNA damage frequently occurs. The molecular mechanisms causing this damage may include activation of nucleases and direct reaction of hydroxyl radicals with the DNA. Several oxygen-derived species can attack DNA, producing distinctive patterns of chemical modification. Observation of these patterns and measurement of some of the products formed has been used to determine the role of different oxygen-derived species in DNA cleavage reactions, to assess the extent of oxidative damage to DNA in vivo and to investigate the mechanism of DNA damage by ionizing radiation and chemical carcinogens.

PMID:: 1849843; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Supplemental Content

Save items

Related citations in PubMed

Review [Free oxygen radiacals and kidney diseases--part I]. [Med Pregl. 2000]
Review [Free oxygen radiacals and kidney diseases--part I].
Sakac V, Sakac M. Med Pregl. 2000 Sep-Oct; 53(9-10):463-74.
Assays for 8-hydroxy-2'-deoxyguanosine: a biomarker of in vivo oxidative DNA damage. [Free Radic Biol Med. 1991]
Assays for 8-hydroxy-2'-deoxyguanosine: a biomarker of in vivo oxidative DNA damage.
Shigenaga MK, Ames BN. Free Radic Biol Med. 1991; 10(3-4):211-6.
Hydroxyl free radical is not the main active species in site-specific DNA damage induced by copper (II) ion and hydrogen peroxide. [J Biol Chem. 1989]
Hydroxyl free radical is not the main active species in site-specific DNA damage induced by copper (II) ion and hydrogen peroxide.
Yamamoto K, Kawanishi S. J Biol Chem. 1989 Sep 15; 264(26):15435-40.
Review Oxygen and nitrogen are pro-carcinogens. Damage to DNA by reactive oxygen, chlorine and nitrogen species: measurement, mechanism and the effects of nutrition. [Mutat Res. 1999]
Review Oxygen and nitrogen are pro-carcinogens. Damage to DNA by reactive oxygen, chlorine and nitrogen species: measurement, mechanism and the effects of nutrition.
Halliwell B. Mutat Res. 1999 Jul 15; 443(1-2):37-52.
Use of repair endonucleases to characterize DNA damage induced by reactive oxygen species in cellular and cell-free systems. [Toxicol Lett. 1993]
Use of repair endonucleases to characterize DNA damage induced by reactive oxygen species in cellular and cell-free systems.
Epe B, Pflaum M, Häring M, Hegler J, Rüdiger H. Toxicol Lett. 1993 Apr; 67(1-3):57-72.

See reviews... See all...

Cited by 64 PubMed Central articles

Maximizing signal-to-noise ratio in the random mutation capture assay. [Nucleic Acids Res. 2012]
Maximizing signal-to-noise ratio in the random mutation capture assay.
Poovathingal SK, Gruber J, Ng LF, Halliwell B, Gunawan R. Nucleic Acids Res. 2012 Mar; 40(5):e35. Epub 2011 Dec 17.
Subcellular distribution of glutathione and its dynamic changes under oxidative stress in the yeast Saccharomyces cerevisiae. [FEMS Yeast Res. 2011]
Subcellular distribution of glutathione and its dynamic changes under oxidative stress in the yeast Saccharomyces cerevisiae.
Zechmann B, Liou LC, Koffler BE, Horvat L, Tomašić A, Fulgosi H, Zhang Z. FEMS Yeast Res. 2011 Dec; 11(8):631-42. Epub 2011 Sep 27.
Relationship between the Extent of DNA Damage and Gastritis in Normal and Helicobacter pylori-Infected Patients. [Gut Liver. 2011]
Relationship between the Extent of DNA Damage and Gastritis in Normal and Helicobacter pylori-Infected Patients.
Marie MA, Altahir IE. Gut Liver. 2011 Sep; 5(3):315-20. Epub 2011 Aug 18.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian...
DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian systems.
FEBS Lett. 1991 Apr 9 ;281(1-2):9-19.

PubMed
Extending the sub-sea-floor biosphere.
Extending the sub-sea-floor biosphere.
Science. 2008 May 23 ;320(5879):1046.

PubMed
Protein stability and molecular adaptation to extreme conditions.
Protein stability and molecular adaptation to extreme conditions.
Eur J Biochem. 1991 Dec 18 ;202(3):715-28.

PubMed
Methane monooxygenase gene expression mediated by methanobactin in the presence ...
Methane monooxygenase gene expression mediated by methanobactin in the presence of mineral copper sources.
Proc Natl Acad Sci U S A. 2007 Jul 17 ;104(29):12040-5. Epub 2007 Jul 5 .

PubMed
Abiotic synthesis of amino acids under hydrothermal conditions and the origin of...
Abiotic synthesis of amino acids under hydrothermal conditions and the origin of life: a perpetual phenomenon?
Naturwissenschaften. 1992 Aug ;79(8):361-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian systems.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 64 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information