Met Based Drugs. 1998;5(4):233-6.

Synthesis and Antifungal Activity of Some Organotin(IV) Carboxylates.

Bonire JJ, Ayoko GA, Olurinola PF, Ehinmidu JO, Jalil NS, Omachi AA.

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Department of Chemistry Ahmadu Bello University Zaria Nigeria.

Abstract

Six diorganotin(IV) carboxylates prepared by reacting diorganotin(IV) dichlorides with the respective silver carboxylate have been tested for antifungal activity against Aspergillus. niger, Aspergilluus flavus and Pencillium. citrinum in Sabourand dextrose broth. The compounds generally exhibit greater fungitoxicity than the diorganotin(IV) dichlorides and the carboxylic acids from which they were synthesized. In keeping with the generally accepted notion that the organotin moiety plays an important role in deciding the antifungal activity of an organotin compound, the diphenyltin(IV) compounds were more active than their di-n-butyltin(IV) analogues. However, the order of increasing fungitoxicity of the compounds parallels that of the uncomplexed carboxylic acids. The implications of the results are discussed.

PMID:: 18475848; [PubMed]
PMCID:: PMC2365116

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