Nat Rev Genet. 2008 Jul;9(7):509-15. Epub 2008 May 13.

Use and misuse of the gene ontology annotations.

Rhee SY, Wood V, Dolinski K, Draghici S.

Source

Carnegie Institution for Science, Department of Plant Biology, 260 Panama Street, Stanford, California 94305, USA. rhee@acoma.stanford.edu

Abstract

The Gene Ontology (GO) project is a collaboration among model organism databases to describe gene products from all organisms using a consistent and computable language. GO produces sets of explicitly defined, structured vocabularies that describe biological processes, molecular functions and cellular components of gene products in both a computer- and human-readable manner. Here we describe key aspects of GO, which, when overlooked, can cause erroneous results, and address how these pitfalls can be avoided.

PMID:: 18475267; [PubMed - indexed for MEDLINE]

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