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    Nature. 1991 Feb 21;349(6311):669-76.

    Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments.

    Source

    Laboratory of Cell Biology, Medical School, University of Utrecht, The Netherlands.

    Abstract

    Traffic of MHC molecules dictates the source of peptides that are presented to T cells. The intracellular distribution of MHC class I and class II molecules reflects the dichotomy in presentation of antigen from endogenous and exogenous origin, respectively. In human B lymphoblastoid cells, class I molecules are present in compartments constituting the biosynthetic pathway, whereas class II molecules enter structures related to lysosomes during their biosynthesis.

    PMID:
    1847504
    [PubMed - indexed for MEDLINE]

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