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    Science. 1991 Feb 15;251(4995):802-4.

    Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product.

    Bottaro DP, Rubin JS, Faletto DL, Chan AM, Kmiecik TE, Vande Woude GF, Aaronson SA.

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    Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892.

    Abstract

    Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral mediator of liver regeneration. A 145-kilodalton tyrosyl phosphoprotein observed in rapid response to HGF treatment of intact target cells was identified by immunoblot analysis as the beta subunit of the c-met proto-oncogene product, a membrane-spanning tyrosine kinase. Covalent cross-linking of 125I-labeled ligand to cellular proteins of appropriate size that were recognized by antibodies to c-met directly established the c-met product as the cell-surface receptor for HGF.

    PMID:
    1846706
    [PubMed - indexed for MEDLINE]

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