Arch Physiol Biochem. 2008 Feb;114(1):45-53.

Insulin analogues: action profiles beyond glycaemic control.

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Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Auf'm Hennekamp 65, Düsseldorf, Germany.

Abstract

A variety of studies have documented significant improvements in the treatment of type 1 and 2 diabetes after the introduction of artificial insulins. This review gives an overview of insulin analogues which are currently approved for therapeutical use. Clinical data regarding the efficiency to control blood glucose level as well as improving HbA1c level in comparison to conventional insulin preparations in type 1 and 2 diabetic patients are summarized. Furthermore, special features of insulin analogues regarding their signalling properties are discussed with focus on the proliferative effects of insulin glargine as well as some recent data of insulin detemir.

PMID:: 18465358; [PubMed - indexed for MEDLINE]

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Cited by 2 PubMed Central articles

Differences in bioactivity between human insulin and insulin analogues approved for therapeutic use- compilation of reports from the past 20 years. [Diabetol Metab Syndr. 2011]
Differences in bioactivity between human insulin and insulin analogues approved for therapeutic use- compilation of reports from the past 20 years.
Werner H, Chantelau EA. Diabetol Metab Syndr. 2011 Jun 29; 3(1):13. Epub 2011 Jun 29.
In vitro metabolic and mitogenic signaling of insulin glargine and its metabolites. [PLoS One. 2010]
In vitro metabolic and mitogenic signaling of insulin glargine and its metabolites.
Sommerfeld MR, Müller G, Tschank G, Seipke G, Habermann P, Kurrle R, Tennagels N. PLoS One. 2010 Mar 4; 5(3):e9540. Epub 2010 Mar 4.

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