Mater Med Pol. 1991 Oct-Dec;23(4):280-4.

Effect of mannitol on intracranial pressure in focal cerebral ischemia. An experimental study in a rat.

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Department of Neurosurgery, Medical Academy, Lódź, Poland.

Abstract

The authors studied the effects of mannitol on intracranial pressure (ICP) in experimental focal ischemia in a rat. Stroke was produced by occlusion of middle cerebral artery (MCA). The study revealed that mannitol decreases ICP in ischemic stroke much less then in healthy animals and also a significant rebound effect was seen, especially in the 5th and 7th day after MCA occlusion. The authors suggest a very limited use of mannitol in clinical treatment of elevated ICP after cerebral ischemic stroke.

PMID:: 1842234; [PubMed - indexed for MEDLINE]

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Comparative Study

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Mannitol

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D-MANNITOL - HSDB

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