Arthritis Res Ther. 2008;10(2):205. Epub 2008 Mar 31.

Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets.

Source

Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300RC Leiden, The Netherlands. AvdHelm@lumc.nl

Abstract

In the past few years considerable advances have been made in the genetics of susceptibility to rheumatoid arthritis (RA). For decades the HLA-DRB1 alleles were the only extensively replicated genetic factor, but more genetic risk factors have now been identified that predispose to RA. Interestingly, several of the observed genetic variants conferred risk to anticitrulline-peptide antibody (ACPA)-positive RA and two variants may be restricted to ACPA-negative RA, pointing to the need for subclassification of RA. The current manuscript reviews recently identified genetic factors predisposing to ACPA-positive RA and ACPA-negative RA. Additionally, although being scarcely explored, genetic variants affecting the severity of disease course are discussed.

PMID:: 18394179; [PubMed - indexed for MEDLINE]
PMCID: PMC2453775

Free PMC Article

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Review [Is rheumatoid arthritis without anti-citrullinated peptide antibody a genetically distinct subset?]. [Nihon Rinsho Meneki Gakkai Kaishi. 2009]
Review [Is rheumatoid arthritis without anti-citrullinated peptide antibody a genetically distinct subset?].
Ohmura K. Nihon Rinsho Meneki Gakkai Kaishi. 2009 Dec; 32(6):484-91.
Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis. [Arthritis Rheum. 2009]
Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis.
van der Woude D, Houwing-Duistermaat JJ, Toes RE, Huizinga TW, Thomson W, Worthington J, van der Helm-van Mil AH, de Vries RR. Arthritis Rheum. 2009 Apr; 60(4):916-23.
Opposing effects of HLA-DRB1*13 alleles on the risk of developing anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis. [Arthritis Rheum. 2009]
Opposing effects of HLA-DRB1*13 alleles on the risk of developing anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis.
Lundström E, Källberg H, Smolnikova M, Ding B, Rönnelid J, Alfredsson L, Klareskog L, Padyukov L. Arthritis Rheum. 2009 Apr; 60(4):924-30.
Review Genetics of ACPA-positive rheumatoid arthritis: the beginning of the end? [Ann Rheum Dis. 2011]
Review Genetics of ACPA-positive rheumatoid arthritis: the beginning of the end?
de Vries RR, van der Woude D, Houwing JJ, Toes RE. Ann Rheum Dis. 2011 Mar; 70 Suppl 1:i51-4.
Anti-citrullinated peptide antibody-negative RA is a genetically distinct subset: a definitive study using only bone-erosive ACPA-negative rheumatoid arthritis. [Rheumatology (Oxford). 2010]
Anti-citrullinated peptide antibody-negative RA is a genetically distinct subset: a definitive study using only bone-erosive ACPA-negative rheumatoid arthritis.
Ohmura K, Terao C, Maruya E, Katayama M, Matoba K, Shimada K, Murasawa A, Honjo S, Takasugi K, Tohma S, et al. Rheumatology (Oxford). 2010 Dec; 49(12):2298-304. Epub 2010 Sep 9.

See reviews... See all...

Cited by 8 PubMed Central articles

A systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis. [PLoS One. 2011]
A systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis.
Nakaoka H, Cui T, Tajima A, Oka A, Mitsunaga S, Kashiwase K, Homma Y, Sato S, Suzuki Y, Inoko H, et al. PLoS One. 2011; 6(9):e25389. Epub 2011 Sep 28.
Review Genetics of rheumatoid arthritis: what have we learned? [Immunogenetics. 2011]
Review Genetics of rheumatoid arthritis: what have we learned?
Bax M, van Heemst J, Huizinga TW, Toes RE. Immunogenetics. 2011 Aug; 63(8):459-66. Epub 2011 May 10.
Effects of GSTM1 in rheumatoid arthritis; results from the Swedish EIRA study. [PLoS One. 2011]
Effects of GSTM1 in rheumatoid arthritis; results from the Swedish EIRA study.
Lundström E, Hartshorne T, Li K, Lindblad S, Wick MC, Bengtsson C, Alfredsson L, Klareskog L, Padyukov L. PLoS One. 2011 Mar 22; 6(3):e17880. Epub 2011 Mar 22.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Advances in the genetics of rheumatoid arthritis point to subclassification into...
Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets.
Arthritis Res Ther. 2008 ;10(2):205. Epub 2008 Mar 31 .

PubMed
Failure to verify H-ras mutations in arthritic synovium: comment on the article ...
Failure to verify H-ras mutations in arthritic synovium: comment on the article by Roivainen et al.
Arthritis Rheum. 2001 Nov ;44(11):2705.

PubMed
Cardiovascular risk factors in women with and without rheumatoid arthritis.
Cardiovascular risk factors in women with and without rheumatoid arthritis.
Arthritis Rheum. 2004 Nov ;50(11):3444-9.

PubMed
The burden of musculoskeletal diseases in the general population of Spain: resul...
The burden of musculoskeletal diseases in the general population of Spain: results from a national survey.
Ann Rheum Dis. 2001 Nov ;60(11):1040-5.

PubMed
Therapeutic strategies to reduce IL-1 activity in treating local and systemic in...
Therapeutic strategies to reduce IL-1 activity in treating local and systemic inflammation.
Curr Opin Pharmacol. 2004 Aug ;4(4):378-85.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: