Trends Parasitol. 2008 Apr;24(4):159-63. Epub 2008 Mar 19.

Simplified antimalarial therapeutic monitoring: using the day-7 drug level?

White NJ, Stepniewska K, Barnes K, Price RN, Simpson J.

Source

Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand. fnnjw@diamond.mahidol.ac.th <fnnjw@diamond.mahidol.ac.th>

Abstract

The blood concentration profiles of most antimalarial drugs vary considerably between patients. The interpretation of antimalarial drug trials evaluating efficacy and effectiveness would be improved considerably if the exposure of the infecting parasite population to the antimalarial drug treatment could be measured. Artemisinin combination treatments are now recommended as first-line drugs for the treatment of falciparum malaria. Measurement of the blood, serum or plasma concentration of the slowly eliminated partner antimalarial drug on day 7 of follow-up is simpler and might be a better determinant of therapeutic response than the area under the concentration-time curve. Measurement of the day-7 drug level should be considered as a routine part of antimalarial drug trials.

PMID:: 18353727; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Malaria - MedlinePlus Health Information

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Review Quantification of the antimalarial piperaquine in plasma. [Trans R Soc Trop Med Hyg. 2008]
Review Quantification of the antimalarial piperaquine in plasma.
Tarning J, Lindegardh N. Trans R Soc Trop Med Hyg. 2008 May; 102(5):409-11.
Review Clinical pharmacology of artemisinin-based combination therapies. [Clin Pharmacokinet. 2008]
Review Clinical pharmacology of artemisinin-based combination therapies.
German PI, Aweeka FT. Clin Pharmacokinet. 2008; 47(2):91-102.
Artemisinin kinetics and dynamics during oral and rectal treatment of uncomplicated malaria. [Clin Pharmacol Ther. 1998]
Artemisinin kinetics and dynamics during oral and rectal treatment of uncomplicated malaria.
Ashton M, Nguyen DS, Nguyen VH, Gordi T, Trinh NH, Dinh XH, Nguyen TN, Le DC. Clin Pharmacol Ther. 1998 Apr; 63(4):482-93.
Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria. [Eur J Clin Pharmacol. 2009]
Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria.
Miller AK, Bandyopadhyay N, Wootton DG, Duparc S, Kirby PL, Winstanley PA, Ward SA. Eur J Clin Pharmacol. 2009 Oct; 65(10):977-87. Epub 2009 Jun 11.
Mefloquine pharmacokinetics and mefloquine-artesunate effectiveness in Peruvian patients with uncomplicated Plasmodium falciparum malaria. [Malar J. 2009]
Mefloquine pharmacokinetics and mefloquine-artesunate effectiveness in Peruvian patients with uncomplicated Plasmodium falciparum malaria.
Gutman J, Green M, Durand S, Rojas OV, Ganguly B, Quezada WM, Utz GC, Slutsker L, Ruebush TK 2nd, Bacon DJ. Malar J. 2009 Apr 9; 8:58. Epub 2009 Apr 9.

See reviews... See all...

Cited by 11 PubMed Central articles

Effects of amodiaquine and artesunate on sulphadoxine-pyrimethamine pharmacokinetic parameters in children under five in Mali. [Malar J. 2011]
Effects of amodiaquine and artesunate on sulphadoxine-pyrimethamine pharmacokinetic parameters in children under five in Mali.
Tekete MM, Toure S, Fredericks A, Beavogui AH, Sangare CP, Evans A, Smith P, Maiga H, Traore ZI, Doumbo OK, et al. Malar J. 2011 Sep 21; 10:275. Epub 2011 Sep 21.
In vivo efficacy of artemether-lumefantrine against uncomplicated Plasmodium falciparum malaria in Central Ethiopia. [Malar J. 2011]
In vivo efficacy of artemether-lumefantrine against uncomplicated Plasmodium falciparum malaria in Central Ethiopia.
Hwang J, Alemayehu BH, Hoos D, Melaku Z, Tekleyohannes SG, Teshi T, Birhanu SG, Demeke L, Gobena K, Kassa M, et al. Malar J. 2011 Jul 28; 10:209. Epub 2011 Jul 28.
Development, evaluation, and application of an in silico model for antimalarial drug treatment and failure. [Antimicrob Agents Chemother. 2...]
Development, evaluation, and application of an in silico model for antimalarial drug treatment and failure.
Winter K, Hastings IM. Antimicrob Agents Chemother. 2011 Jul; 55(7):3380-92. Epub 2011 May 2.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Simplified antimalarial therapeutic monitoring: using the day-7 drug level?
Simplified antimalarial therapeutic monitoring: using the day-7 drug level?
Trends Parasitol. 2008 Apr ;24(4):159-63. Epub 2008 Mar 19 .

PubMed
A single amino acid in the second Ig-like domain of the human Fc gamma receptor ...
A single amino acid in the second Ig-like domain of the human Fc gamma receptor II is critical for human IgG2 binding.
J Immunol. 1991 Aug 15 ;147(4):1338-43.

PubMed
An experimental hut evaluation of Olyset nets against anopheline mosquitoes afte...
An experimental hut evaluation of Olyset nets against anopheline mosquitoes after seven years use in Tanzanian villages.
Malar J. 2008 Feb 28 ;7:38.

PubMed
Chloroquine-induced pruritus: its impact on chloroquine utilization in malaria c...
Chloroquine-induced pruritus: its impact on chloroquine utilization in malaria control in Dar es Salaam.
J Trop Med Hyg. 1991 Feb ;94(1):27-31.

PubMed
Malaria reemergence in northern Afghanistan.
Malaria reemergence in northern Afghanistan.
Emerg Infect Dis. 2007 Sep ;13(9):1402-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Simplified antimalarial therapeutic monitoring: using the day-7 drug level?

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 11 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information