Science. 1991 Oct 11;254(5029):274-7.

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region.

Bellacosa A, Testa JR, Staal SP, Tsichlis PN.

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Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111.

Abstract

The v-akt oncogene codes for a 105-kilodalton fusion phosphoprotein containing Gag sequences at its amino terminus. Sequence analysis of v-akt and biochemical characterization of its product revealed that it codes for a protein kinase C-related serine-threonine kinase whose cellular homolog is expressed in most tissues, with the highest amount found in thymus. Although Akt is a serine-threonine kinase, part of its regulatory region is similar to the Src homology-2 domain, a structural motif characteristic of cytoplasmic tyrosine kinases that functions in protein-protein interactions. This suggests that Akt may form a functional link between tyrosine and serine-threonine phosphorylation pathways.

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A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region.

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