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    J Cell Physiol. 2008 Jun;215(3):794-802.

    SEL1L and HRD1 are involved in the degradation of unassembled secretory Ig-mu chains.

    Cattaneo M, Otsu M, Fagioli C, Martino S, Lotti LV, Sitia R, Biunno I.

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    Institute for Biomedical Technologies, National Research Council, Segrate, Milan, Italy.

    Abstract

    When expressed in the absence of light chains, secretory Ig-micro chains (micro(s)) undergo endoplasmic reticulum associated degradation (ERAD). This process involves the recognition of terminally misfolded or unassembled molecules, their retro-translocation across the ER membrane and ubiquitination for degradation by cytosolic proteasomes. The molecular components of the ERAD pathway and their coordination remain largely unknown. Here we employed co-immunoprecipitation, silencing or over-expression assays to show that SEL1L and HRD1 are involved in the degradation of unassembled Ig-micro(s), but have minor effects on another substrate, TCR-alpha. SEL1L and HRD1 localize in the early secretory apparatus and are induced by ER stress and during B cell differentiation, concomitantly with the onset of massive IgM secretion. These findings reveal a role for SEL1L and HRD1 in IgM quality control.

    (c) 2008 Wiley-Liss, Inc.

    PMID:
    18314878
    [PubMed - indexed for MEDLINE]

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