Trop Med Int Health. 2008 Feb;13(2):238-40.

Chloroquine-resistance molecular markers (Pfcrt T76 and Pfmdr-1 Y86) and amodiaquine resistance in Burkina Faso.

Tinto H, Guekoun L, Zongo I, Guiguemdé RT, D'Alessandro U, Ouédraogo JB.

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Institut de Recherche en Sciences de la Santé (IRSS), Bobo Dioulasso, Burkina Faso, and Centre Muraz, Bobo Dioulasso, Burkina Faso. tintohalidou@yahoo.fr

Abstract

We investigated the relationship between the two main molecular markers for chloroquine resistance (Pfcrt T76 and Pfmdr-1 Y86) and the clinical efficacy of amodiaquine in Burkina Faso. Before treatment, the prevalence of Pfcrt T76, Pfmdr-1 Y86 or both mutations in the same infection was significantly higher in patients who experienced a recrudescence than in those who successfully responded to the treatment. Therefore, these two molecular markers could be useful in monitoring amodiaquine resistance, particularly in countries where this drug is used in combination with artesunate as first- or second-line treatment.

PMID:: 18304270; [PubMed - indexed for MEDLINE]

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Chemical compound information

Chloroquine

MW: 319.87 g/mol

MF: C₁₈H₂₆ClN₃

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Chloroquine-resistance molecular markers (Pfcrt T76 and Pfmdr-1 Y86) and amodiaquine resistance in Burkina Faso.

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