Curr Opin Drug Discov Devel. 2008 Mar;11(2):217-24.

Delivering silence: advancements in developing siRNA therapeutics.

Novobrantseva TI, Akinc A, Borodovsky A, de Fougerolles A.

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Alnylam Pharmaceuticals Inc, 300 Third Street, Cambridge, MA 02142, USA. tnovobrantseva@alnylam.com

Abstract

The number of small interfering RNA (siRNA)-based therapeutics that are in or nearing human clinical trials is rapidly expanding. This review summarizes recent in vivo data obtained from studies on siRNA therapeutics and gives an overview of the key in vivo delivery technologies in use today. A section is also devoted to currently ongoing clinical trials employing siRNA drugs.

PMID:: 18283609; [PubMed - indexed for MEDLINE]

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Review Delivery vehicles for small interfering RNA in vivo. [Hum Gene Ther. 2008]
Review Delivery vehicles for small interfering RNA in vivo.
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Cited by 3 PubMed Central articles

In vivo quantification of formulated and chemically modified small interfering RNA by heating-in-Triton quantitative reverse transcription polymerase chain reaction (HIT qRT-PCR). [Silence. 2010]
In vivo quantification of formulated and chemically modified small interfering RNA by heating-in-Triton quantitative reverse transcription polymerase chain reaction (HIT qRT-PCR).
Landesman Y, Svrzikapa N, Cognetta A 3rd, Zhang X, Bettencourt BR, Kuchimanchi S, Dufault K, Shaikh S, Gioia M, Akinc A, et al. Silence. 2010 Aug 23; 1(1):16. Epub 2010 Aug 23.
A status report on RNAi therapeutics. [Silence. 2010]
A status report on RNAi therapeutics.
Vaishnaw AK, Gollob J, Gamba-Vitalo C, Hutabarat R, Sah D, Meyers R, de Fougerolles T, Maraganore J. Silence. 2010 Jul 8; 1(1):14. Epub 2010 Jul 8.
Sequence determinants of innate immune activation by short interfering RNAs. [BMC Immunol. 2009]
Sequence determinants of innate immune activation by short interfering RNAs.
Goodchild A, Nopper N, King A, Doan T, Tanudji M, Arndt GM, Poidinger M, Rivory LP, Passioura T. BMC Immunol. 2009 Jul 24; 10:40. Epub 2009 Jul 24.

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