J Clin Oncol. 2008 Feb 10;26(5):729-35.

Clinical application of the 70-gene profile: the MINDACT trial.

Cardoso F, Van't Veer L, Rutgers E, Loi S, Mook S, Piccart-Gebhart MJ.

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Jules Bordet Institute, Blvd de Waterloo, 125, 1000 Brussels, Belgium.

Abstract

The 70-gene profile is a new prognostic tool that has the potential to greatly improve risk assessment and treatment decision making for early breast cancer. Its prospective validation is currently ongoing through the MINDACT (Microarray in Node-Negative Disease May Avoid Chemotherapy) trial, a 6,000-patient randomized, multicentric trial. This article reviews the several steps in the development of the profile from its discovery to its clinical validation.

PMID:: 18258980; [PubMed - indexed for MEDLINE]

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The MINDACT trial: the first prospective clinical validation of a genomic tool. [Mol Oncol. 2007]
The MINDACT trial: the first prospective clinical validation of a genomic tool.
Cardoso F, Piccart-Gebhart M, Van't Veer L, Rutgers E, TRANSBIG Consortium. Mol Oncol. 2007 Dec; 1(3):246-51. Epub 2007 Oct 22.
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