Breast Cancer Res. 2008;10(1):301. Epub 2008 Jan 18.

The role of single nucleotide polymorphisms in breast cancer metastasis.

Rae JM, Skaar TC, Hilsenbeck SG, Oesterreich S.

Source

Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USA. jimmyrae@umich.edu

Abstract

Our understanding of many aspects of cancer biology has been advanced through the use of modern genetics. These studies have already shown that germ line polymorphisms play a significant role in disease initiation and response to therapy. However, what is less well studied is the role of germ line polymorphisms in cancer progression. Studies in rodents indicate that differential susceptibility to cancer metastasis can be heritable; thus, the search for the genes that control cancer metastasis is underway. Although some provocative studies suggest potential candidates for metastasis regulating genes, the conclusive identification of a specific inherited genetic variant that alters metastatic potential awaits further studies.

PMID:: 18226176; [PubMed - indexed for MEDLINE]
PMCID: PMC2374952

Free PMC Article

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Breast Cancer - MedlinePlus Health Information

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Review Germline polymorphisms are potential metastasis risk and prognosis markers in breast cancer. [Breast Dis. 2006]
Review Germline polymorphisms are potential metastasis risk and prognosis markers in breast cancer.
Hsieh SM, Lintell NA, Hunter KW. Breast Dis. 2006-2007; 26:157-62.
Interleukin gene polymorphisms and breast cancer: a case control study and systematic literature review. [BMC Cancer. 2006]
Interleukin gene polymorphisms and breast cancer: a case control study and systematic literature review.
Balasubramanian SP, Azmy IA, Higham SE, Wilson AG, Cross SS, Cox A, Brown NJ, Reed MW. BMC Cancer. 2006 Jul 14; 6:188. Epub 2006 Jul 14.
Review Host genetics influence tumour metastasis. [Nat Rev Cancer. 2006]
Review Host genetics influence tumour metastasis.
Hunter K. Nat Rev Cancer. 2006 Feb; 6(2):141-6.
Mitochondrial NADH-dehydrogenase polymorphisms as sporadic breast cancer risk factor. [Oncol Rep. 2010]
Mitochondrial NADH-dehydrogenase polymorphisms as sporadic breast cancer risk factor.
Czarnecka AM, Klemba A, Krawczyk T, Zdrozny M, Arnold RS, Bartnik E, Petros JA. Oncol Rep. 2010 Feb; 23(2):531-5.
Association of BCL10 germ line polymorphisms on chromosome 1p with advanced stage testicular germ cell tumor patients. [Cancer Lett. 2006]
Association of BCL10 germ line polymorphisms on chromosome 1p with advanced stage testicular germ cell tumor patients.
Inoue T, Ito T, Narita S, Horikawa Y, Tsuchiya N, Kakinuma H, Mishina M, Nakamura E, Kato T, Ogawa O, et al. Cancer Lett. 2006 Aug 18; 240(1):41-7. Epub 2005 Oct 17.

See reviews... See all...

Cited by 1 PubMed Central article

The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor. [J Biol Chem. 2009]
The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor.
Crawford NP, Yang H, Mattaini KR, Hunter KW. J Biol Chem. 2009 Oct 16; 284(42):28660-73. Epub 2009 Aug 26.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The role of single nucleotide polymorphisms in breast cancer metastasis.
The role of single nucleotide polymorphisms in breast cancer metastasis.
Breast Cancer Res. 2008 ;10(1):301. Epub 2008 Jan 18 .

PubMed
Mitochondria as the central control point of apoptosis.
Mitochondria as the central control point of apoptosis.
Trends Cell Biol. 2000 Sep ;10(9):369-77.

PubMed
Oncogene-induced senescence pathways weave an intricate tapestry.
Oncogene-induced senescence pathways weave an intricate tapestry.
Cell. 2007 Jan 26 ;128(2):233-4.

PubMed
Ten genes for inherited breast cancer.
Ten genes for inherited breast cancer.
Cancer Cell. 2007 Feb ;11(2):103-5.

PubMed
Clinical trial update: National Cancer Institute of Canada.
Clinical trial update: National Cancer Institute of Canada.
Breast Cancer Res. 2005 ;7(2):48-51. Epub 2005 Jan 12 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

The role of single nucleotide polymorphisms in breast cancer metastasis.

Source

Abstract

MeSH Terms

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Libraries

Supplemental Content

Related citations

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information