J Trace Elem Electrolytes Health Dis. 1991 Dec;5(4):261-3.

Serum zinc, copper and selenium in rheumatoid arthritis.

Honkanen V, Konttinen YT, Sorsa T, Hukkanen M, Kemppinen P, Santavirta S, Saari H, Westermarck T.

Source

Fourth Department of Medicine, Central Hospital, Helsinki, Finland.

Abstract

Rheumatoid arthritis (RA) is characterized by low serum Zn and high serum Cu. In multiple linear regression both were explained by disease activity parameters. It is suggested that interleukin-1 causes both changes by 1) increasing the metallothionein-mediated hepatic uptake to serum Zn and 2) upregulating ceruloplasmin (acute phase reactant) gene and synthesis in liver and subsequently the level of ceruloplasmin-Cu complexes in the blood. Cu absorption was diminished by zinc intake. Cu- and Zn-dependent erythrocyte SOD was increased in RA. In contrast to plasma GSHPx serum selenium was low in RA and this was associated with disease activity parameters.

PMID:: 1822334; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Medical

Molecular Biology Databases

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

[Levels of Cu, Zn, Se and their relation to levels of ceruloplasmin and the activity of antioxidative enzymes]. [Bratisl Lek Listy. 1997]
[Levels of Cu, Zn, Se and their relation to levels of ceruloplasmin and the activity of antioxidative enzymes].
Magálová T, Beno I, Brtková A, Mekinová D, Volkovová K, Staruchová M, Tatara M. Bratisl Lek Listy. 1997 Jan; 98(1):8-11.
Serum copper and erythrocyte superoxide dismutase in rheumatoid arthritis. [Ann Rheum Dis. 1982]
Serum copper and erythrocyte superoxide dismutase in rheumatoid arthritis.
Banford JC, Brown DH, Hazelton RA, McNeil CJ, Sturrock RD, Smith WE. Ann Rheum Dis. 1982 Oct; 41(5):458-62.
Effects of tobacco smoking on plasma selenium, zinc, copper and iron concentrations and related antioxidative enzyme activities. [Clin Biochem. 2001]
Effects of tobacco smoking on plasma selenium, zinc, copper and iron concentrations and related antioxidative enzyme activities.
Kocyigit A, Erel O, Gur S. Clin Biochem. 2001 Nov; 34(8):629-33.
Review Selenium and the selenium-dependent glutathione peroxidase in rheumatoid arthritis. [Dan Med Bull. 1994]
Review Selenium and the selenium-dependent glutathione peroxidase in rheumatoid arthritis.
Tarp U. Dan Med Bull. 1994 Jun; 41(3):264-74.
Review Hyperzincemia from ingestion of denture adhesives. [J Prosthet Dent. 2010]
Review Hyperzincemia from ingestion of denture adhesives.
Tezvergil-Mutluay A, Carvalho RM, Pashley DH. J Prosthet Dent. 2010 Jun; 103(6):380-3.

See reviews... See all...

Cited by 3 PubMed Central articles

Effect of allopurinol and vitamin e on rat model of rheumatoid arthritis. [Int J Health Sci (Qassim). 2008]
Effect of allopurinol and vitamin e on rat model of rheumatoid arthritis.
Alorainy M. Int J Health Sci (Qassim). 2008 Jan; 2(1):59-67.
Copper chelation with tetrathiomolybdate suppresses adjuvant-induced arthritis and inflammation-associated cachexia in rats. [Arthritis Res Ther. 2005]
Copper chelation with tetrathiomolybdate suppresses adjuvant-induced arthritis and inflammation-associated cachexia in rats.
Omoto A, Kawahito Y, Prudovsky I, Tubouchi Y, Kimura M, Ishino H, Wada M, Yoshida M, Kohno M, Yoshimura R, et al. Arthritis Res Ther. 2005; 7(6):R1174-82. Epub 2005 Aug 8.
Antioxidant intake, plasma antioxidants and oxidative stress in a randomized, controlled, parallel, Mediterranean dietary intervention study on patients with rheumatoid arthritis. [Nutr J. 2003]
Antioxidant intake, plasma antioxidants and oxidative stress in a randomized, controlled, parallel, Mediterranean dietary intervention study on patients with rheumatoid arthritis.
Hagfors L, Leanderson P, Sköldstam L, Andersson J, Johansson G. Nutr J. 2003 Jul 30; 2:5. Epub 2003 Jul 30.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Serum zinc, copper and selenium in rheumatoid arthritis.
Serum zinc, copper and selenium in rheumatoid arthritis.
J Trace Elem Electrolytes Health Dis. 1991 Dec ;5(4):261-3.

PubMed
Negative inotropic effects of high-mobility group box 1 protein in isolated cont...
Negative inotropic effects of high-mobility group box 1 protein in isolated contracting cardiac myocytes.
Am J Physiol Heart Circ Physiol. 2008 Mar ;294(3):H1490-6. Epub 2008 Jan 25 .

PubMed
Incidence and risk factors for gout in white men.
Incidence and risk factors for gout in white men.
JAMA. 1991 Dec 4 ;266(21):3004-7.

PubMed
A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is as...
A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.
Nat Genet. 2008 Feb ;40(2):152-4. Epub 2008 Jan 20 .

PubMed
[Monoclonal gammopathies of undetermined significance. Clinical course and biolo...
[Monoclonal gammopathies of undetermined significance. Clinical course and biological aspects of 397 cases].
Sangre (Barc). 1991 Oct ;36(5):377-82.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Serum zinc, copper and selenium in rheumatoid arthritis.

Source

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Medical

Molecular Biology Databases

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 3 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information