University of Kuopio, Department of Biosciences, Laboratory of Chemistry, PO Box 1627, FIN-70211, Kuopio, Finland. petri.turhanen@uku.fi.
ABSTRACT: Unexpected degradation of the P-C-P bridge from novel bisphosphonate derivative 1a and known etidronate trimethyl ester (1b) has been observed under mild reaction conditions. A proposed reaction mechanism for the unexpected degradation of 1a and 1b is also reported.