Planta Med. 1991 Dec;57(6):552-4.

A novel leishmanicidal labdane from Polyalthia macropoda.

Richomme P, Godet MC, Foussard F, Toupet L, Sévenet T, Bruneton J.

Source

C.E.P.M., Faculté de Pharmacie, Angers, France.

Abstract

A new diterpene, (4S,9R,10R) methyl 18-carboxy-labda-8,13(E)-diene-15-oate has been obtained from the stem barks of Polyalthia macropoda (Annonaceae). This labdanic derivative was identified on the basis of spectroscopic data and is biologically active against the promastigote Leishmania donovani donovani.

PMID:: 1818347; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Antileishmanial activity of natural diterpenes from Cistus sp. and semisynthetic derivatives thereof. [Biol Pharm Bull. 2006]
Antileishmanial activity of natural diterpenes from Cistus sp. and semisynthetic derivatives thereof.
Fokialakis N, Kalpoutzakis E, Tekwani BL, Skaltsounis AL, Duke SO. Biol Pharm Bull. 2006 Aug; 29(8):1775-8.
Complete structural assignment of serratol, a cembrane-type diterpene from Boswellia serrata, and evaluation of its antiprotozoal activity. [Planta Med. 2011]
Complete structural assignment of serratol, a cembrane-type diterpene from Boswellia serrata, and evaluation of its antiprotozoal activity.
Schmidt TJ, Kaiser M, Brun R. Planta Med. 2011 May; 77(8):849-50. Epub 2010 Dec 14.
Antiprotozoal polyacetylenes from the Tanzanian medicinal plant Cussonia zimmermannii. [J Nat Prod. 2007]
Antiprotozoal polyacetylenes from the Tanzanian medicinal plant Cussonia zimmermannii.
Senn M, Gunzenhauser S, Brun R, Séquin U. J Nat Prod. 2007 Oct; 70(10):1565-9. Epub 2007 Oct 9.
16alpha-Hydroxycleroda-3,13 (14)Z-dien-15,16-olide from Polyalthia longifolia: a safe and orally active antileishmanial agent. [Br J Pharmacol. 2010]
16alpha-Hydroxycleroda-3,13 (14)Z-dien-15,16-olide from Polyalthia longifolia: a safe and orally active antileishmanial agent.
Misra P, Sashidhara KV, Singh SP, Kumar A, Gupta R, Chaudhaery SS, Gupta SS, Majumder HK, Saxena AK, Dube A. Br J Pharmacol. 2010 Mar; 159(5):1143-50. Epub 2010 Feb 5.
Review Diterpenoids of terrestrial origin. [Nat Prod Rep. 2011]
Review Diterpenoids of terrestrial origin.
Hanson JR. Nat Prod Rep. 2011 Oct; 28(10):1755-72. Epub 2011 Jun 28.

See reviews... See all...

Cited by 1 PubMed Central article

In vitro antileishmanial effects of antibacterial diterpenes from two Ethiopian Premna species: P. schimperi and P. oligotricha. [BMC Pharmacol. 2003]
In vitro antileishmanial effects of antibacterial diterpenes from two Ethiopian Premna species: P. schimperi and P. oligotricha.
Habtemariam S. BMC Pharmacol. 2003 Jun 6; 3:6. Epub 2003 Jun 6.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

A novel leishmanicidal labdane from Polyalthia macropoda.
A novel leishmanicidal labdane from Polyalthia macropoda.
Planta Med. 1991 Dec ;57(6):552-4.

PubMed
Signal-regulated Pre-mRNA occupancy by the general splicing factor U2AF.
Signal-regulated Pre-mRNA occupancy by the general splicing factor U2AF.
PLoS One. 2008 Jan 9 ;3(1):e1418.

PubMed
Change in the established prescribing habits of general practitioners: an analys...
Change in the established prescribing habits of general practitioners: an analysis of initial prescriptions in general practice.
Br J Gen Pract. 1991 Jun ;41(347):244-8.

PubMed
Childhood diet, overweight, and CVD risk factors: the Healthy Start project.
Childhood diet, overweight, and CVD risk factors: the Healthy Start project.
Prev Cardiol. 2008 Winter ;11(1):11-20.

PubMed
Repeat injection after a "failed spinal": at times, a potentially unsafe practic...
Repeat injection after a "failed spinal": at times, a potentially unsafe practice.
Anesthesiology. 1991 Oct ;75(4):713-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: