Eur J Cancer. 1991;27(12):1639-42.

Resistance modification by PSC-833, a novel non-immunosuppressive cyclosporin [corrected].

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MRC Clinical Oncology, Radiotherapeutics Unit, Cambridge, U.K.

Erratum in

Eur J Cancer 1992;28(2-3):616.

Abstract

A novel non-immunosuppressive cyclosporin [corrected], PSC-833, has been tested for its ability to circumvent resistance to doxorubicin, vincristine and colchicine in human and murine multidrug resistant (MDR) cell lines. This compound is shown to be a highly potent resistance modifier, being 7-10-fold more potent than the parent compound, cyclosporin A, whilst approximately equal to cyclosporin A in the growth inhibitory effects of compound alone. Reversal of the P-glycoprotein-associated MDR drug accumulation defect is a major component of resistance reversal for PSC-833, as it is for cyclosporin A.

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